HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation

HRD1 (3-hydroxy-3-methylglutaryl reductase degradation) is an E3 ubiquitin ligase. We found that HRD1 was significantly downregulated in 170 breast cancer tissues. Low tumoral HRD1 expression was correlated with clinicopathological characteristics and a shorter survival in breast cancer patients. P6...

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Detalles Bibliográficos
Autores principales: Xu, Yue-Mei, Wang, Hong-Jiang, Chen, Fang, Guo, Wan-Hua, Wang, Yan-Yang, Li, Hang-Yu, Tang, Jin-Hai, Ding, Ying, Shen, Ya-Chen, Li, Min, Xuan, Wen-Ying, Liu, Lin-Hui, Wang, Jia, Wang, Xue-Rong, Gao, Ze-Jun, Liang, Xiu-Bin, Su, Dong-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767476/
https://www.ncbi.nlm.nih.gov/pubmed/26536657

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