Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis

The DNA glycosylase gene MBD4 safeguards genomic stability at CpG sites and is frequently mutated at coding poly-A tracks in mismatch repair (MMR)-defective colorectal tumors (CRC). Mbd4 biallelic inactivation in mice provided conflicting results as to its role in tumorigenesis. Thus, it is unclear...

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Detalles Bibliográficos
Autores principales: Tricarico, Rossella, Cortellino, Salvatore, Riccio, Antonio, Jagmohan-Changur, Shantie, van der Klift, Heleen, Wijnen, Juul, Turner, David, Ventura, Andrea, Rovella, Valentina, Percesepe, Antonio, Lucci-Cordisco, Emanuela, Radice, Paolo, Bertario, Lucio, Pedroni, Monica, de Leon, Maurizio Ponz, Mancuso, Pietro, Devarajan, Karthik, Cai, Kathy Q., Klein-Szanto, Andres J.P., Neri, Giovanni, Møller, Pål, Viel, Alessandra, Genuardi, Maurizio, Fodde, Riccardo, Bellacosa, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767479/
https://www.ncbi.nlm.nih.gov/pubmed/26503472

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