TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner

Our neoadjuvant clinical trial of a GM-CSF secreting allogeneic pancreas tumor vaccine (GVAX) revealed the development of tertiary lymphoid aggregates (TLAs) within the pancreatic ductal adenocarcinoma (PDA) tumor microenvironment 2 weeks after GVAX treatment. Microarray studies revealed that multip...

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Detalles Bibliográficos
Autores principales: Soares, Kevin C., Rucki, Agnieszka A., Kim, Victoria, Foley, Kelly, Solt, Sara, Wolfgang, Christopher L., Jaffee, Elizabeth M., Zheng, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767487/
https://www.ncbi.nlm.nih.gov/pubmed/26515728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767487/
https://www.ncbi.nlm.nih.gov/pubmed/26515728

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