An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma

Translocation events are frequent in cancer and may create chimeric fusions or ‘regulatory rearrangements’ that drive oncogene overexpression. Here we identify super-enhancer translocations that drive overexpression of the oncogenic transcription factor MYB as a recurrent theme in adenoid cystic car...

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Detalles Bibliográficos
Autores principales: Drier, Yotam, Cotton, Matthew J., Williamson, Kaylyn E., Gillespie, Shawn M., Ryan, Russell J.H., Kluk, Michael J., Carey, Christopher D., Rodig, Scott J., Sholl, Lynette M, Afrogheh, Amir H., Faquin, William C., Queimado, Lurdes, Qi, Jun, Wick, Michael J., El-Naggar, Adel K., Bradner, James E., Moskaluk, Christopher A., Aster, Jon C., Knoechel, Birgit, Bernstein, Bradley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767593/
https://www.ncbi.nlm.nih.gov/pubmed/26829750
http://dx.doi.org/10.1038/ng.3502

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