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Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism

OBJECTIVES: To test the hypothesis that testosterone replacement therapy (TRT) improves the long-term health-related quality of life (HRQoL) of men with late-onset hypogonadism (LOH), as studies have shown that sub-physiological testosterone levels have a negative impact on psychological (e.g. mood,...

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Autores principales: Almehmadi, Yousef, Yassin, Aksam A., Nettleship, Joanne E., Saad, Farid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767784/
https://www.ncbi.nlm.nih.gov/pubmed/26966591
http://dx.doi.org/10.1016/j.aju.2015.10.002
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author Almehmadi, Yousef
Yassin, Aksam A.
Nettleship, Joanne E.
Saad, Farid
author_facet Almehmadi, Yousef
Yassin, Aksam A.
Nettleship, Joanne E.
Saad, Farid
author_sort Almehmadi, Yousef
collection PubMed
description OBJECTIVES: To test the hypothesis that testosterone replacement therapy (TRT) improves the long-term health-related quality of life (HRQoL) of men with late-onset hypogonadism (LOH), as studies have shown that sub-physiological testosterone levels have a negative impact on psychological (e.g. mood, vitality, libido and sexual interest) and physical features (e.g. erectile function and physical strength), all of which contribute to a sense of well-being. PATIENTS AND METHODS: In all, 261 patients (mean age 58 years) diagnosed with LOH were treated with long-acting intramuscular testosterone undecanoate (TU) for up to 5 years. Health quality indicators including the International Prostate Symptom Score (IPSS), the five-item version of the International Index of Erectile Function (IIEF-5), the Aging Males’ Symptoms (AMS) scale, and the percentage of patients reporting joint and muscle pain were measured at baseline and at each visit. The means were then plotted over time in parallel with mean total testosterone (TT) levels. RESULTS: Both the mean IPSS and AMS scores fell significantly within the first 3 months and the mean IIEF-5 score and TT levels increased within the first 3 months. All four parameters continued to improve over the course of the trial. The percentage of patients reporting both joint and muscle pain decreased during TRT. CONCLUSIONS: This prospective, observational and longitudinal analysis shows a clear improvement in both psychological and physical characteristics as physiological testosterone levels are reached and maintained contributing to an improvement in the HRQoL in men with diagnosed LOH.
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spelling pubmed-47677842016-03-10 Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism Almehmadi, Yousef Yassin, Aksam A. Nettleship, Joanne E. Saad, Farid Arab J Urol Andrology/Sexual Medicine Original article OBJECTIVES: To test the hypothesis that testosterone replacement therapy (TRT) improves the long-term health-related quality of life (HRQoL) of men with late-onset hypogonadism (LOH), as studies have shown that sub-physiological testosterone levels have a negative impact on psychological (e.g. mood, vitality, libido and sexual interest) and physical features (e.g. erectile function and physical strength), all of which contribute to a sense of well-being. PATIENTS AND METHODS: In all, 261 patients (mean age 58 years) diagnosed with LOH were treated with long-acting intramuscular testosterone undecanoate (TU) for up to 5 years. Health quality indicators including the International Prostate Symptom Score (IPSS), the five-item version of the International Index of Erectile Function (IIEF-5), the Aging Males’ Symptoms (AMS) scale, and the percentage of patients reporting joint and muscle pain were measured at baseline and at each visit. The means were then plotted over time in parallel with mean total testosterone (TT) levels. RESULTS: Both the mean IPSS and AMS scores fell significantly within the first 3 months and the mean IIEF-5 score and TT levels increased within the first 3 months. All four parameters continued to improve over the course of the trial. The percentage of patients reporting both joint and muscle pain decreased during TRT. CONCLUSIONS: This prospective, observational and longitudinal analysis shows a clear improvement in both psychological and physical characteristics as physiological testosterone levels are reached and maintained contributing to an improvement in the HRQoL in men with diagnosed LOH. Elsevier 2016-03 2015-11-27 /pmc/articles/PMC4767784/ /pubmed/26966591 http://dx.doi.org/10.1016/j.aju.2015.10.002 Text en © 2015 Arab Association of Urology. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Andrology/Sexual Medicine Original article
Almehmadi, Yousef
Yassin, Aksam A.
Nettleship, Joanne E.
Saad, Farid
Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism
title Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism
title_full Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism
title_fullStr Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism
title_full_unstemmed Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism
title_short Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism
title_sort testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism
topic Andrology/Sexual Medicine Original article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767784/
https://www.ncbi.nlm.nih.gov/pubmed/26966591
http://dx.doi.org/10.1016/j.aju.2015.10.002
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