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Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs
The presence of a microenvironment within most tumours containing regions of low oxygen tension or hypoxia has profound biological and therapeutic implications. Tumour hypoxia is known to promote the development of an aggressive phenotype, resistance to both chemotherapy and radiotherapy and is stro...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767869/ https://www.ncbi.nlm.nih.gov/pubmed/26811177 http://dx.doi.org/10.1007/s00280-015-2920-7 |