Flow Cytometry To Assess Cerebrospinal Fluid Fungal Burden in Cryptococcal Meningitis

Fungal burden in the cerebrospinal fluid is an important determinant of mortality in cryptococcal meningitis, but its use in aiding clinical decision making is hampered by the time involved to perform quantitative cultures. Here, we demonstrate the potential of flow cytometry as a novel and rapid te...

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Detalles Bibliográficos
Autores principales: Scriven, James E., Graham, Lisa M., Schutz, Charlotte, Scriba, Thomas J., Wilkinson, Robert J., Boulware, David R., Meintjes, Graeme, Lalloo, David G., Urban, Britta C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Mycology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767993/
https://www.ncbi.nlm.nih.gov/pubmed/26719441
http://dx.doi.org/10.1128/JCM.03002-15
Descripción
Sumario:Fungal burden in the cerebrospinal fluid is an important determinant of mortality in cryptococcal meningitis, but its use in aiding clinical decision making is hampered by the time involved to perform quantitative cultures. Here, we demonstrate the potential of flow cytometry as a novel and rapid technique to address this issue.

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