Cargando…
Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome
Neurogenesis impairment starting from early developmental stages is a key determinant of intellectual disability in Down syndrome (DS). Previous evidence provided a causal relationship between neurogenesis impairment and malfunctioning of the mitogenic Sonic Hedgehog (Shh) pathway. In particular, ex...
Autores principales: | Giacomini, Andrea, Stagni, Fiorenza, Trazzi, Stefania, Guidi, Sandra, Emili, Marco, Brigham, Elizabeth, Ciani, Elisabetta, Bartesaghi, Renata |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768084/ https://www.ncbi.nlm.nih.gov/pubmed/26254735 http://dx.doi.org/10.1016/j.nbd.2015.08.001 |
Ejemplares similares
-
Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome
por: Stagni, Fiorenza, et al.
Publicado: (2017) -
Timing of Treatment with the Flavonoid 7,8-DHF Critically Impacts on Its Effects on Learning and Memory in the Ts65Dn Mouse
por: Giacomini, Andrea, et al.
Publicado: (2019) -
Impaired Brain Mitochondrial Bioenergetics in the Ts65Dn Mouse Model of Down Syndrome Is Restored by Neonatal Treatment with the Polyphenol 7,8-Dihydroxyflavone
por: Valenti, Daniela, et al.
Publicado: (2021) -
Pharmacotherapy with Fluoxetine Restores Functional Connectivity from the Dentate Gyrus to Field CA3 in the Ts65Dn Mouse Model of Down Syndrome
por: Stagni, Fiorenza, et al.
Publicado: (2013) -
Hypocellularity in the Murine Model for Down Syndrome Ts65Dn Is Not Affected by Adult Neurogenesis
por: López-Hidalgo, Rosa, et al.
Publicado: (2016)