Interaction between the NS4B amphipathic helix, AH2, and charged lipid headgroups alters membrane morphology and AH2 oligomeric state — Implications for the Hepatitis C virus life cycle

The non-structural protein 4B (NS4B) from Hepatitis C virus (HCV) plays a pivotal role in the remodelling of the host cell's membranes, required for the formation of the viral replication complex where genome synthesis occurs. NS4B is an integral membrane protein that possesses a number of doma...

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Detalles Bibliográficos
Autores principales: Ashworth Briggs, Esther L., Gomes, Rafael G.B., Elhussein, Malaz, Collier, William, Stuart Findlow, I., Khalid, Syma, McCormick, Chris J., Williamson, Philip T.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768108/
https://www.ncbi.nlm.nih.gov/pubmed/25944559
http://dx.doi.org/10.1016/j.bbamem.2015.04.015

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