Heterologous Production of the Marine Myxobacterial Antibiotic Haliangicin and Its Unnatural Analogues Generated by Engineering of the Biochemical Pathway

Despite their fastidious nature, marine myxobacteria have considerable genetic potential to produce novel secondary metabolites. The marine myxobacterium Haliangium ochraceum SMP-2 produces the antifungal polyketide haliangicin (1), but its productivity is unsatisfactory. The biosynthetic gene clust...

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Detalles Bibliográficos
Autores principales: Sun, Yuwei, Feng, Zhiyang, Tomura, Tomohiko, Suzuki, Akira, Miyano, Seishi, Tsuge, Takashi, Mori, Hitoshi, Suh, Joo-Won, Iizuka, Takashi, Fudou, Ryosuke, Ojika, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768178/
https://www.ncbi.nlm.nih.gov/pubmed/26915413
http://dx.doi.org/10.1038/srep22091

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