Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration

PURPOSE: nab-paclitaxel demonstrates improved clinical efficacy compared with conventional Cremophor EL (CrEL)-paclitaxel in multiple tumor types. This study explored the distinctions in drug distribution between nab-paclitaxel and CrEL-paclitaxel and the underlying mechanisms. METHODS: Uptake and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Nianhang, Brachmann, Carrie, Liu, Xiping, Pierce, Daniel W., Dey, Joyoti, Kerwin, William S., Li, Yan, Zhou, Simon, Hou, Shihe, Carleton, Michael, Klinghoffer, Richard A., Palmisano, Maria, Chopra, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768222/
https://www.ncbi.nlm.nih.gov/pubmed/26231955
http://dx.doi.org/10.1007/s00280-015-2833-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768222/
https://www.ncbi.nlm.nih.gov/pubmed/26231955
http://dx.doi.org/10.1007/s00280-015-2833-5

Ejemplares similares