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Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: implication for tissue function and oncogenesis

Purpose The goal of these studies was to test if local excess of a normal nucleobase substrate prevents the toxicity of protracted 5FU exposure used in human cancer treatment. Methods Messenger RNA expression studies were performed of 5FU activating enzymes in human colon cancer cells lines (CaCo-2,...

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Detalles Bibliográficos
Autores principales:	Vanden Heuvel, John P., Thompson, Jerry T., Albrecht, Prajakta, Mandetta, Donald, Kamerow, Harry, Ford, John P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2015
Materias:	Preclinical Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768230/ https://www.ncbi.nlm.nih.gov/pubmed/26123924 http://dx.doi.org/10.1007/s10637-015-0259-x

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