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A Micro-Thermal Sensor for Focal Therapy Applications

There is an urgent need for sensors deployed during focal therapies to inform treatment planning and in vivo monitoring in thin tissues. Specifically, the measurement of thermal properties, cooling surface contact, tissue thickness, blood flow and phase change with mm to sub mm accuracy are needed....

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Autores principales: Natesan, Harishankar, Hodges, Wyatt, Choi, Jeunghwan, Lubner, Sean, Dames, Chris, Bischof, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768245/
https://www.ncbi.nlm.nih.gov/pubmed/26916460
http://dx.doi.org/10.1038/srep21395
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author Natesan, Harishankar
Hodges, Wyatt
Choi, Jeunghwan
Lubner, Sean
Dames, Chris
Bischof, John
author_facet Natesan, Harishankar
Hodges, Wyatt
Choi, Jeunghwan
Lubner, Sean
Dames, Chris
Bischof, John
author_sort Natesan, Harishankar
collection PubMed
description There is an urgent need for sensors deployed during focal therapies to inform treatment planning and in vivo monitoring in thin tissues. Specifically, the measurement of thermal properties, cooling surface contact, tissue thickness, blood flow and phase change with mm to sub mm accuracy are needed. As a proof of principle, we demonstrate that a micro-thermal sensor based on the supported “3ω” technique can achieve this in vitro under idealized conditions in 0.5 to 2 mm thick tissues relevant to cryoablation of the pulmonary vein (PV). To begin with “3ω” sensors were microfabricated onto flat glass as an idealization of a focal probe surface. The sensor was then used to make new measurements of ‘k’ (W/m.K) of porcine PV, esophagus, and phrenic nerve, all needed for PV cryoabalation treatment planning. Further, by modifying the sensor use from traditional to dynamic mode new measurements related to tissue vs. fluid (i.e. water) contact, fluid flow conditions, tissue thickness, and phase change were made. In summary, the in vitro idealized system data presented is promising and warrants future work to integrate and test supported “3ω” sensors on in vivo deployed focal therapy probe surfaces (i.e. balloons or catheters).
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spelling pubmed-47682452016-03-02 A Micro-Thermal Sensor for Focal Therapy Applications Natesan, Harishankar Hodges, Wyatt Choi, Jeunghwan Lubner, Sean Dames, Chris Bischof, John Sci Rep Article There is an urgent need for sensors deployed during focal therapies to inform treatment planning and in vivo monitoring in thin tissues. Specifically, the measurement of thermal properties, cooling surface contact, tissue thickness, blood flow and phase change with mm to sub mm accuracy are needed. As a proof of principle, we demonstrate that a micro-thermal sensor based on the supported “3ω” technique can achieve this in vitro under idealized conditions in 0.5 to 2 mm thick tissues relevant to cryoablation of the pulmonary vein (PV). To begin with “3ω” sensors were microfabricated onto flat glass as an idealization of a focal probe surface. The sensor was then used to make new measurements of ‘k’ (W/m.K) of porcine PV, esophagus, and phrenic nerve, all needed for PV cryoabalation treatment planning. Further, by modifying the sensor use from traditional to dynamic mode new measurements related to tissue vs. fluid (i.e. water) contact, fluid flow conditions, tissue thickness, and phase change were made. In summary, the in vitro idealized system data presented is promising and warrants future work to integrate and test supported “3ω” sensors on in vivo deployed focal therapy probe surfaces (i.e. balloons or catheters). Nature Publishing Group 2016-02-26 /pmc/articles/PMC4768245/ /pubmed/26916460 http://dx.doi.org/10.1038/srep21395 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Natesan, Harishankar
Hodges, Wyatt
Choi, Jeunghwan
Lubner, Sean
Dames, Chris
Bischof, John
A Micro-Thermal Sensor for Focal Therapy Applications
title A Micro-Thermal Sensor for Focal Therapy Applications
title_full A Micro-Thermal Sensor for Focal Therapy Applications
title_fullStr A Micro-Thermal Sensor for Focal Therapy Applications
title_full_unstemmed A Micro-Thermal Sensor for Focal Therapy Applications
title_short A Micro-Thermal Sensor for Focal Therapy Applications
title_sort micro-thermal sensor for focal therapy applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768245/
https://www.ncbi.nlm.nih.gov/pubmed/26916460
http://dx.doi.org/10.1038/srep21395
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