Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development

Nucleoprotein (NP) is the most abundant type of RNA-binding viral protein in influenza A virus–infected cells and is necessary for viral RNA transcription and replication. Recent studies demonstrated that influenza NP is a valid target for antiviral drug development. The surface of the groove, cover...

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Detalles Bibliográficos
Autores principales: Liu, Chia-Lin, Hung, Hui-Chen, Lo, Shou-Chen, Chiang, Ching-Hui, Chen, I-Jung, Hsu, John T.-A., Hou, Ming-Hon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768256/
https://www.ncbi.nlm.nih.gov/pubmed/26916998
http://dx.doi.org/10.1038/srep21662

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