Cargando…
Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle
Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccination of cattle. However, vaccine protection is undermined by population turnover and declining immunity. A dynamic model of the Turkish cattle population was created. Assuming biannual mass vaccination with a single-dose...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768268/ https://www.ncbi.nlm.nih.gov/pubmed/26916556 http://dx.doi.org/10.1038/srep22121 |
_version_ | 1782417921649147904 |
---|---|
author | Knight-Jones, T. J. D. Gubbins, S. Bulut, A. N. Stärk, K. D. C. Pfeiffer, D. U. Sumption, K. J. Paton, D. J. |
author_facet | Knight-Jones, T. J. D. Gubbins, S. Bulut, A. N. Stärk, K. D. C. Pfeiffer, D. U. Sumption, K. J. Paton, D. J. |
author_sort | Knight-Jones, T. J. D. |
collection | PubMed |
description | Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccination of cattle. However, vaccine protection is undermined by population turnover and declining immunity. A dynamic model of the Turkish cattle population was created. Assuming biannual mass vaccination with a single-dose primary course, vaccine history was calculated for the simulated population (number of doses and time since last vaccination). This was used to estimate population immunity. Six months after the last round of vaccination almost half the cattle aged <24 months remain unvaccinated. Only 50% of all cattle would have received >1 vaccine dose in their life with the last dose given ≤6 months ago. Five months after the last round of vaccination two-thirds of cattle would have low antibody titres (<70% protection threshold). Giving a two-dose primary vaccination course reduces the proportion of 6–12 month old cattle with low titres by 20–30%. Biannual mass vaccination of cattle leaves significant immunity gaps and over-reliance on vaccine protection should be avoided. Using more effective vaccines and vaccination strategies will increase population immunity, however, the extent to which FMD can be controlled by vaccination alone without effective biosecurity remains uncertain. |
format | Online Article Text |
id | pubmed-4768268 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47682682016-03-02 Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle Knight-Jones, T. J. D. Gubbins, S. Bulut, A. N. Stärk, K. D. C. Pfeiffer, D. U. Sumption, K. J. Paton, D. J. Sci Rep Article Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccination of cattle. However, vaccine protection is undermined by population turnover and declining immunity. A dynamic model of the Turkish cattle population was created. Assuming biannual mass vaccination with a single-dose primary course, vaccine history was calculated for the simulated population (number of doses and time since last vaccination). This was used to estimate population immunity. Six months after the last round of vaccination almost half the cattle aged <24 months remain unvaccinated. Only 50% of all cattle would have received >1 vaccine dose in their life with the last dose given ≤6 months ago. Five months after the last round of vaccination two-thirds of cattle would have low antibody titres (<70% protection threshold). Giving a two-dose primary vaccination course reduces the proportion of 6–12 month old cattle with low titres by 20–30%. Biannual mass vaccination of cattle leaves significant immunity gaps and over-reliance on vaccine protection should be avoided. Using more effective vaccines and vaccination strategies will increase population immunity, however, the extent to which FMD can be controlled by vaccination alone without effective biosecurity remains uncertain. Nature Publishing Group 2016-02-26 /pmc/articles/PMC4768268/ /pubmed/26916556 http://dx.doi.org/10.1038/srep22121 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Knight-Jones, T. J. D. Gubbins, S. Bulut, A. N. Stärk, K. D. C. Pfeiffer, D. U. Sumption, K. J. Paton, D. J. Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle |
title | Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle |
title_full | Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle |
title_fullStr | Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle |
title_full_unstemmed | Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle |
title_short | Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle |
title_sort | mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in turkish cattle |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768268/ https://www.ncbi.nlm.nih.gov/pubmed/26916556 http://dx.doi.org/10.1038/srep22121 |
work_keys_str_mv | AT knightjonestjd massvaccinationimmunityandcoveragemodellingpopulationprotectionagainstfootandmouthdiseaseinturkishcattle AT gubbinss massvaccinationimmunityandcoveragemodellingpopulationprotectionagainstfootandmouthdiseaseinturkishcattle AT bulutan massvaccinationimmunityandcoveragemodellingpopulationprotectionagainstfootandmouthdiseaseinturkishcattle AT starkkdc massvaccinationimmunityandcoveragemodellingpopulationprotectionagainstfootandmouthdiseaseinturkishcattle AT pfeifferdu massvaccinationimmunityandcoveragemodellingpopulationprotectionagainstfootandmouthdiseaseinturkishcattle AT sumptionkj massvaccinationimmunityandcoveragemodellingpopulationprotectionagainstfootandmouthdiseaseinturkishcattle AT patondj massvaccinationimmunityandcoveragemodellingpopulationprotectionagainstfootandmouthdiseaseinturkishcattle |