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High prevalence of being Overweight and Obese HIV-infected persons, before and after 24 months on early ART in the ANRS 12136 Temprano Trial

BACKGROUND: HIV is usually associated with weight loss. World health Organization (WHO) recommends early antiretroviral (ART) initiation, but data on the progression of body mass index (BMI) in participants initiating early ART in Africa are scarce. METHODS: The Temprano randomized trial was conduct...

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Autores principales: Guehi, Calixte, Badjé, Anani, Gabillard, Delphine, Ouattara, Eric, Koulé, Serge Olivier, Moh, Raoul, Ekouevi, Didier, Ahibo, Hugues, N’Takpé, Jean Baptiste, Menan, Gérard Kouamé, Deschamps, Nina, Lecarrou, Jerôme, Eholié, Serge, Anglaret, Xavier, Danel, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768327/
https://www.ncbi.nlm.nih.gov/pubmed/26925155
http://dx.doi.org/10.1186/s12981-016-0094-y
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author Guehi, Calixte
Badjé, Anani
Gabillard, Delphine
Ouattara, Eric
Koulé, Serge Olivier
Moh, Raoul
Ekouevi, Didier
Ahibo, Hugues
N’Takpé, Jean Baptiste
Menan, Gérard Kouamé
Deschamps, Nina
Lecarrou, Jerôme
Eholié, Serge
Anglaret, Xavier
Danel, Christine
author_facet Guehi, Calixte
Badjé, Anani
Gabillard, Delphine
Ouattara, Eric
Koulé, Serge Olivier
Moh, Raoul
Ekouevi, Didier
Ahibo, Hugues
N’Takpé, Jean Baptiste
Menan, Gérard Kouamé
Deschamps, Nina
Lecarrou, Jerôme
Eholié, Serge
Anglaret, Xavier
Danel, Christine
author_sort Guehi, Calixte
collection PubMed
description BACKGROUND: HIV is usually associated with weight loss. World health Organization (WHO) recommends early antiretroviral (ART) initiation, but data on the progression of body mass index (BMI) in participants initiating early ART in Africa are scarce. METHODS: The Temprano randomized trial was conducted in Abidjan to assess the effectiveness of early ART and Isoniazid (INH) prophylaxis for tuberculosis in HIV-infected persons with high CD4 counts below 800 cells/mm(3) without any indication for starting ART. Patients initiating early ART before December 2010 were included in this sub-study. BMI was categorized as: underweight (<18.5 kg/m(2)), normal weight (18.5–24.9 kg/m(2)), overweight (25–29.9 kg/m(2)) and obese (≥30 kg/m(2)). At baseline and after 24 months of ART, prevalence of being overweight or obese and factors associated with being overweight or obese were estimated using univariate and multivariate logistic regression. RESULTS: At baseline, 755 participants (78 % women; median CD4 count 442/mm(3), median baseline BMI 22 kg/m(2)) initiated ART. Among them, 19.7 % were overweight, and 7.2 % were obese at baseline. Factors associated with being overweight or obese were: female sex aOR 2.3 (95 % CI 1.4–3.7), age, aOR for 5 years 1.01 (95 % CI 1.0–1.2), high living conditions aOR 2.6 (95 % CI 1.5–4.4), High blood pressure aOR 4.3 (95 % CI 2.0–9.2), WHO stage 2vs1 aOR 0.7 (95 % CI 0.4–1.0) and Hemoglobin ≥95 g/dl aOR 3.0 (95 % CI 1.6–5.8). Among the 597 patients who attended the M24 visit, being overweight or obese increased from 20.4 to 24.8 % (p = 0.01) and 7.2 to 9.2 % (p = 0.03) respectively and factor associated with being overweight or obese was immunological response measured as an increase of CD4 cell count between M0–M24 (for +50 cells/mm(3): aOR 1.01; 95 % CI 1.05–1.13, p = 0.01). CONCLUSION: The weight categories overweight and obese are highly prevalent in HIV-infected persons with high CD4 cell counts at baseline, and increased over 24 months on ART in this Sub-Saharan African population.
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spelling pubmed-47683272016-02-27 High prevalence of being Overweight and Obese HIV-infected persons, before and after 24 months on early ART in the ANRS 12136 Temprano Trial Guehi, Calixte Badjé, Anani Gabillard, Delphine Ouattara, Eric Koulé, Serge Olivier Moh, Raoul Ekouevi, Didier Ahibo, Hugues N’Takpé, Jean Baptiste Menan, Gérard Kouamé Deschamps, Nina Lecarrou, Jerôme Eholié, Serge Anglaret, Xavier Danel, Christine AIDS Res Ther Research BACKGROUND: HIV is usually associated with weight loss. World health Organization (WHO) recommends early antiretroviral (ART) initiation, but data on the progression of body mass index (BMI) in participants initiating early ART in Africa are scarce. METHODS: The Temprano randomized trial was conducted in Abidjan to assess the effectiveness of early ART and Isoniazid (INH) prophylaxis for tuberculosis in HIV-infected persons with high CD4 counts below 800 cells/mm(3) without any indication for starting ART. Patients initiating early ART before December 2010 were included in this sub-study. BMI was categorized as: underweight (<18.5 kg/m(2)), normal weight (18.5–24.9 kg/m(2)), overweight (25–29.9 kg/m(2)) and obese (≥30 kg/m(2)). At baseline and after 24 months of ART, prevalence of being overweight or obese and factors associated with being overweight or obese were estimated using univariate and multivariate logistic regression. RESULTS: At baseline, 755 participants (78 % women; median CD4 count 442/mm(3), median baseline BMI 22 kg/m(2)) initiated ART. Among them, 19.7 % were overweight, and 7.2 % were obese at baseline. Factors associated with being overweight or obese were: female sex aOR 2.3 (95 % CI 1.4–3.7), age, aOR for 5 years 1.01 (95 % CI 1.0–1.2), high living conditions aOR 2.6 (95 % CI 1.5–4.4), High blood pressure aOR 4.3 (95 % CI 2.0–9.2), WHO stage 2vs1 aOR 0.7 (95 % CI 0.4–1.0) and Hemoglobin ≥95 g/dl aOR 3.0 (95 % CI 1.6–5.8). Among the 597 patients who attended the M24 visit, being overweight or obese increased from 20.4 to 24.8 % (p = 0.01) and 7.2 to 9.2 % (p = 0.03) respectively and factor associated with being overweight or obese was immunological response measured as an increase of CD4 cell count between M0–M24 (for +50 cells/mm(3): aOR 1.01; 95 % CI 1.05–1.13, p = 0.01). CONCLUSION: The weight categories overweight and obese are highly prevalent in HIV-infected persons with high CD4 cell counts at baseline, and increased over 24 months on ART in this Sub-Saharan African population. BioMed Central 2016-02-25 /pmc/articles/PMC4768327/ /pubmed/26925155 http://dx.doi.org/10.1186/s12981-016-0094-y Text en © Guehi et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Guehi, Calixte
Badjé, Anani
Gabillard, Delphine
Ouattara, Eric
Koulé, Serge Olivier
Moh, Raoul
Ekouevi, Didier
Ahibo, Hugues
N’Takpé, Jean Baptiste
Menan, Gérard Kouamé
Deschamps, Nina
Lecarrou, Jerôme
Eholié, Serge
Anglaret, Xavier
Danel, Christine
High prevalence of being Overweight and Obese HIV-infected persons, before and after 24 months on early ART in the ANRS 12136 Temprano Trial
title High prevalence of being Overweight and Obese HIV-infected persons, before and after 24 months on early ART in the ANRS 12136 Temprano Trial
title_full High prevalence of being Overweight and Obese HIV-infected persons, before and after 24 months on early ART in the ANRS 12136 Temprano Trial
title_fullStr High prevalence of being Overweight and Obese HIV-infected persons, before and after 24 months on early ART in the ANRS 12136 Temprano Trial
title_full_unstemmed High prevalence of being Overweight and Obese HIV-infected persons, before and after 24 months on early ART in the ANRS 12136 Temprano Trial
title_short High prevalence of being Overweight and Obese HIV-infected persons, before and after 24 months on early ART in the ANRS 12136 Temprano Trial
title_sort high prevalence of being overweight and obese hiv-infected persons, before and after 24 months on early art in the anrs 12136 temprano trial
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768327/
https://www.ncbi.nlm.nih.gov/pubmed/26925155
http://dx.doi.org/10.1186/s12981-016-0094-y
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