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The positive frequency-dependent electrophysiological effects of the I(Kur) inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation
BACKGROUND: Selective inhibitors of K(v)1.5 channels are being developed for the treatment of atrial fibrillation (AF). OBJECTIVES: The purpose of this study was to investigate the effects of the highly selective K(v)1.5 inhibitor XEN-D0103 on human atrial action potentials (APs) at high excitation...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768384/ https://www.ncbi.nlm.nih.gov/pubmed/26455450 http://dx.doi.org/10.1016/j.hrthm.2015.10.003 |