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Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma
The natural killer group 2 member D (NKG2D) receptor and its ligands are important mediators of immune responses to tumors. NKG2D ligands are overexpressed in several malignant tumor types; however, the prognostic value of these ligands is unclear. Here, we aimed to elucidate the role of NKG2D ligan...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768394/ https://www.ncbi.nlm.nih.gov/pubmed/26608587 http://dx.doi.org/10.1111/cas.12853 |
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author | Tsukagoshi, Mariko Wada, Satoshi Yokobori, Takehiko Altan, Bolag Ishii, Norihiro Watanabe, Akira Kubo, Norio Saito, Fumiyoshi Araki, Kenichiro Suzuki, Hideki Hosouchi, Yasuo Kuwano, Hiroyuki |
author_facet | Tsukagoshi, Mariko Wada, Satoshi Yokobori, Takehiko Altan, Bolag Ishii, Norihiro Watanabe, Akira Kubo, Norio Saito, Fumiyoshi Araki, Kenichiro Suzuki, Hideki Hosouchi, Yasuo Kuwano, Hiroyuki |
author_sort | Tsukagoshi, Mariko |
collection | PubMed |
description | The natural killer group 2 member D (NKG2D) receptor and its ligands are important mediators of immune responses to tumors. NKG2D ligands are overexpressed in several malignant tumor types; however, the prognostic value of these ligands is unclear. Here, we aimed to elucidate the role of NKG2D ligands in extrahepatic cholangiocarcinoma (EHCC). We therefore investigated the expression of the NKG2D receptor and its ligands MHC class I chain‐related proteins A and B (MICA/B), unique long 16 binding protein (ULBP) 1, and ULBP2/5/6 in resected specimens from 82 patients with EHCC. All NKG2D ligands were highly expressed in EHCC. High expression of MICA/B or ULBP2/5/6 correlated with overall and disease‐free survival. In contrast, high expression of ULBP1 was significantly associated with improved overall survival, but not disease‐free survival. Concurrent high expression of multiple NKG2D ligands revealed significantly better overall and disease‐free survival than that observed with the overexpression of any one NKG2D ligand. Co‐expression of multiple NKG2D ligands was an independent prognostic indicator of improved survival. Furthermore, co‐overexpression of multiple NKG2D ligands was significantly correlated with high expression of the NKG2D receptor. Inhibiting interactions between multiple NKG2D ligands and the NKG2D receptor might be a promising approach for controlling cancer progression and improving patient prognosis in EHCC. |
format | Online Article Text |
id | pubmed-4768394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47683942016-04-01 Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma Tsukagoshi, Mariko Wada, Satoshi Yokobori, Takehiko Altan, Bolag Ishii, Norihiro Watanabe, Akira Kubo, Norio Saito, Fumiyoshi Araki, Kenichiro Suzuki, Hideki Hosouchi, Yasuo Kuwano, Hiroyuki Cancer Sci Original Articles The natural killer group 2 member D (NKG2D) receptor and its ligands are important mediators of immune responses to tumors. NKG2D ligands are overexpressed in several malignant tumor types; however, the prognostic value of these ligands is unclear. Here, we aimed to elucidate the role of NKG2D ligands in extrahepatic cholangiocarcinoma (EHCC). We therefore investigated the expression of the NKG2D receptor and its ligands MHC class I chain‐related proteins A and B (MICA/B), unique long 16 binding protein (ULBP) 1, and ULBP2/5/6 in resected specimens from 82 patients with EHCC. All NKG2D ligands were highly expressed in EHCC. High expression of MICA/B or ULBP2/5/6 correlated with overall and disease‐free survival. In contrast, high expression of ULBP1 was significantly associated with improved overall survival, but not disease‐free survival. Concurrent high expression of multiple NKG2D ligands revealed significantly better overall and disease‐free survival than that observed with the overexpression of any one NKG2D ligand. Co‐expression of multiple NKG2D ligands was an independent prognostic indicator of improved survival. Furthermore, co‐overexpression of multiple NKG2D ligands was significantly correlated with high expression of the NKG2D receptor. Inhibiting interactions between multiple NKG2D ligands and the NKG2D receptor might be a promising approach for controlling cancer progression and improving patient prognosis in EHCC. John Wiley and Sons Inc. 2016-02-02 2016-02 /pmc/articles/PMC4768394/ /pubmed/26608587 http://dx.doi.org/10.1111/cas.12853 Text en © 2015 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Tsukagoshi, Mariko Wada, Satoshi Yokobori, Takehiko Altan, Bolag Ishii, Norihiro Watanabe, Akira Kubo, Norio Saito, Fumiyoshi Araki, Kenichiro Suzuki, Hideki Hosouchi, Yasuo Kuwano, Hiroyuki Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma |
title | Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma |
title_full | Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma |
title_fullStr | Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma |
title_full_unstemmed | Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma |
title_short | Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma |
title_sort | overexpression of natural killer group 2 member d ligands predicts favorable prognosis in cholangiocarcinoma |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768394/ https://www.ncbi.nlm.nih.gov/pubmed/26608587 http://dx.doi.org/10.1111/cas.12853 |
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