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Heritability of Health and Aging Limitations on Personally Desired Activities
The aim of this study is to estimate heritability of incident limitations on personally desired activities within the eighth decade of life. We measured self-rated ability to perform ten personally desired activities in 1606 male veteran twin pairs at baseline and four years later. At follow-up, 33%...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768531/ https://www.ncbi.nlm.nih.gov/pubmed/26973959 http://dx.doi.org/10.4081/hpr.2015.1981 |
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author | Gurland, Barry J. Page, William Small, Brent McArdle, John J. Plassman, Brenda L. |
author_facet | Gurland, Barry J. Page, William Small, Brent McArdle, John J. Plassman, Brenda L. |
author_sort | Gurland, Barry J. |
collection | PubMed |
description | The aim of this study is to estimate heritability of incident limitations on personally desired activities within the eighth decade of life. We measured self-rated ability to perform ten personally desired activities in 1606 male veteran twin pairs at baseline and four years later. At follow-up, 33% of the cohort reported more limitations in desired activities. Among twins who completed both assessments, there were no statistically significant differences in incidence rates of limitations as a function of zygosity. Sensitivity tests showed the same for change scores; and that, if cognitive impairment or death are deemed to belong among limitations of desired activities, zygosity contributed 10% to new limitations at follow-up. Maintaining personally desired activities over four years in the eighth decade is not subject to substantial genetic influence. However, if death and cognitive impairment are added to incident limitations, then genetics plays a modest role. In all cases, unique environment is the predominant influence. |
format | Online Article Text |
id | pubmed-4768531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-47685312016-03-11 Heritability of Health and Aging Limitations on Personally Desired Activities Gurland, Barry J. Page, William Small, Brent McArdle, John J. Plassman, Brenda L. Health Psychol Res Article The aim of this study is to estimate heritability of incident limitations on personally desired activities within the eighth decade of life. We measured self-rated ability to perform ten personally desired activities in 1606 male veteran twin pairs at baseline and four years later. At follow-up, 33% of the cohort reported more limitations in desired activities. Among twins who completed both assessments, there were no statistically significant differences in incidence rates of limitations as a function of zygosity. Sensitivity tests showed the same for change scores; and that, if cognitive impairment or death are deemed to belong among limitations of desired activities, zygosity contributed 10% to new limitations at follow-up. Maintaining personally desired activities over four years in the eighth decade is not subject to substantial genetic influence. However, if death and cognitive impairment are added to incident limitations, then genetics plays a modest role. In all cases, unique environment is the predominant influence. PAGEPress Publications, Pavia, Italy 2015-04-13 /pmc/articles/PMC4768531/ /pubmed/26973959 http://dx.doi.org/10.4081/hpr.2015.1981 Text en ©Copyright B. J. Gurland et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Gurland, Barry J. Page, William Small, Brent McArdle, John J. Plassman, Brenda L. Heritability of Health and Aging Limitations on Personally Desired Activities |
title | Heritability of Health and Aging Limitations on Personally Desired Activities |
title_full | Heritability of Health and Aging Limitations on Personally Desired Activities |
title_fullStr | Heritability of Health and Aging Limitations on Personally Desired Activities |
title_full_unstemmed | Heritability of Health and Aging Limitations on Personally Desired Activities |
title_short | Heritability of Health and Aging Limitations on Personally Desired Activities |
title_sort | heritability of health and aging limitations on personally desired activities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768531/ https://www.ncbi.nlm.nih.gov/pubmed/26973959 http://dx.doi.org/10.4081/hpr.2015.1981 |
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