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Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs

BACKGROUND—: Cardiovascular side effects associated with cyclooxygenase-2 inhibitor drugs dominate clinical concern. Cyclooxygenase-2 is expressed in the renal medulla where inhibition causes fluid retention and increased blood pressure. However, the mechanisms linking cyclooxygenase-2 inhibition an...

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Detalles Bibliográficos
Autores principales:	Ahmetaj-Shala, Blerina, Kirkby, Nicholas S., Knowles, Rebecca, Al’Yamani, Malak, Mazi, Sarah, Wang, Zhen, Tucker, Arthur T., Mackenzie, Louise, Armstrong, Paul C. J., Nüsing, Rolf M., Tomlinson, James A. P., Warner, Timothy D., Leiper, James, Mitchell, Jane A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768634/ https://www.ncbi.nlm.nih.gov/pubmed/25492024 http://dx.doi.org/10.1161/CIRCULATIONAHA.114.011591

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