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Prevalence of chromosomal abnormalities in infertile couples in romania

The purpose of this study was to establish a correlation between the presence of chromosomal abnormalities in one of the partners and infertility. This retrospective study was performed at the Department of Reproductive Medicine, Life Memorial Hospital, Bucharest, Romania, between August 2007 to Dec...

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Autores principales: Mierla, D, Malageanu, M, Tulin, R, Albu, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Macedonian Science of Sciences and Arts 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768822/
https://www.ncbi.nlm.nih.gov/pubmed/26929902
http://dx.doi.org/10.1515/bjmg-2015-0002
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author Mierla, D
Malageanu, M
Tulin, R
Albu, D
author_facet Mierla, D
Malageanu, M
Tulin, R
Albu, D
author_sort Mierla, D
collection PubMed
description The purpose of this study was to establish a correlation between the presence of chromosomal abnormalities in one of the partners and infertility. This retrospective study was performed at the Department of Reproductive Medicine, Life Memorial Hospital, Bucharest, Romania, between August 2007 to December 2011. Two thousand, one hundred and ninety-five patients with reproductive problems were investigated, and the frequency of chromosomal abnormalities was calculated. The control group consisting of 87 fertile persons who had two or more children, was investigated in this retrospective study. All the patients of this study were investigated by cytogenetic techniques and the results of the two groups were compared by a two-tailed Fisher’s exact test. In this study, 94.99% patients had a normal karyotype and 5.01% had chromosomal abnormalities (numerical and structural chromosomal abnormalities). In the study group, numerical chromosomal abnormalities were detected in 1.14% of infertile men and 0.62% of infertile women, and structural chromosomal abnormalities were detected in 1.38% of infertile men and 1.87% of infertile women, respectively. The correlation between the incidence of chromosomal anomalies in the two sexes in couple with reproductive problems was not statistically significant. Recently, a possible association between infertility and chromosomal abnormalities with a significant statistical association has been reported. Our study shows that there is no association between chromosomal abnormalities and infertility, but this study needs to be confirmed with further investigations and a larger control group to establish the role of chromosomal abnormalities in the etiology of infertility.
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spelling pubmed-47688222016-02-29 Prevalence of chromosomal abnormalities in infertile couples in romania Mierla, D Malageanu, M Tulin, R Albu, D Balkan J Med Genet Original Article The purpose of this study was to establish a correlation between the presence of chromosomal abnormalities in one of the partners and infertility. This retrospective study was performed at the Department of Reproductive Medicine, Life Memorial Hospital, Bucharest, Romania, between August 2007 to December 2011. Two thousand, one hundred and ninety-five patients with reproductive problems were investigated, and the frequency of chromosomal abnormalities was calculated. The control group consisting of 87 fertile persons who had two or more children, was investigated in this retrospective study. All the patients of this study were investigated by cytogenetic techniques and the results of the two groups were compared by a two-tailed Fisher’s exact test. In this study, 94.99% patients had a normal karyotype and 5.01% had chromosomal abnormalities (numerical and structural chromosomal abnormalities). In the study group, numerical chromosomal abnormalities were detected in 1.14% of infertile men and 0.62% of infertile women, and structural chromosomal abnormalities were detected in 1.38% of infertile men and 1.87% of infertile women, respectively. The correlation between the incidence of chromosomal anomalies in the two sexes in couple with reproductive problems was not statistically significant. Recently, a possible association between infertility and chromosomal abnormalities with a significant statistical association has been reported. Our study shows that there is no association between chromosomal abnormalities and infertility, but this study needs to be confirmed with further investigations and a larger control group to establish the role of chromosomal abnormalities in the etiology of infertility. Macedonian Science of Sciences and Arts 2015-12-30 /pmc/articles/PMC4768822/ /pubmed/26929902 http://dx.doi.org/10.1515/bjmg-2015-0002 Text en © Macedonian Academy of Sciences and Arts This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs license (http://creativecommons.org/licenses/by-nc-nd/3.0/), which means that the text may be used for non-commercial purposes, provided credit is given to the author.
spellingShingle Original Article
Mierla, D
Malageanu, M
Tulin, R
Albu, D
Prevalence of chromosomal abnormalities in infertile couples in romania
title Prevalence of chromosomal abnormalities in infertile couples in romania
title_full Prevalence of chromosomal abnormalities in infertile couples in romania
title_fullStr Prevalence of chromosomal abnormalities in infertile couples in romania
title_full_unstemmed Prevalence of chromosomal abnormalities in infertile couples in romania
title_short Prevalence of chromosomal abnormalities in infertile couples in romania
title_sort prevalence of chromosomal abnormalities in infertile couples in romania
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768822/
https://www.ncbi.nlm.nih.gov/pubmed/26929902
http://dx.doi.org/10.1515/bjmg-2015-0002
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