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PRMT5-Mediated Methylation of NF-κB p65 at Arg(174) Is Required for Endothelial CXCL11 Gene Induction in Response to TNF-α and IFN-γ Costimulation
Inflammatory agonists differentially activate gene expression of the chemokine family of proteins in endothelial cells (EC). TNF is a weak inducer of the chemokine CXCL11, while TNF and IFN-γ costimulation results in potent CXCL11 induction. The molecular mechanisms underlying TNF plus IFN-γ-mediate...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768879/ https://www.ncbi.nlm.nih.gov/pubmed/26901772 http://dx.doi.org/10.1371/journal.pone.0148905 |