Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1

Cancer cells are characterized by metabolic alterations, namely, depressed mitochondrial oxidation, enhanced glycolysis and pentose phosphate shunt flux to support rapid cell growth, which is called the Warburg effect. In our study we assessed the metabolic consequences of a joint treatment of MCF-7...

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Detalles Bibliográficos
Autores principales: Fodor, Tamás, Szántó, Magdolna, Abdul-Rahman, Omar, Nagy, Lilla, Dér, Ádám, Kiss, Borbála, Bai, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769015/
https://www.ncbi.nlm.nih.gov/pubmed/26919657
http://dx.doi.org/10.1371/journal.pone.0150232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769015/
https://www.ncbi.nlm.nih.gov/pubmed/26919657
http://dx.doi.org/10.1371/journal.pone.0150232

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