Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells

Constitutive expression of active Akt (Akt(tg)) drives hyperplasia and hypertrophy of pancreatic β-cells, concomitantly with increased insulin secretion and improved glucose tolerance, and at a later stage the development of insulinoma. To determine which functions of Akt are mediated by ribosomal p...

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Detalles Bibliográficos
Autores principales: Wittenberg, Avigail Dreazen, Azar, Shahar, Klochendler, Agnes, Stolovich-Rain, Miri, Avraham, Shlomit, Birnbaum, Lea, Binder Gallimidi, Adi, Katz, Maximiliano, Dor, Yuval, Meyuhas, Oded
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769037/
https://www.ncbi.nlm.nih.gov/pubmed/26919188
http://dx.doi.org/10.1371/journal.pone.0149995

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