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Control of HIV-1 replication in vitro by vaccine-induced human CD8(+) T cells through conserved subdominant Pol epitopes

OBJECTIVE: The specificity of CD8(+) T cells is critical for early control of founder/transmitted and reactivated HIV-1. To tackle HIV-1 variability and escape, we designed vaccine immunogen HIVconsv assembled from 14 highly conserved regions of mainly Gag and Pol proteins. When administered to HIV-...

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Detalles Bibliográficos
Autores principales:	Ahmed, Tina, Borthwick, Nicola J., Gilmour, Jill, Hayes, Peter, Dorrell, Lucy, Hanke, Tomáš
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769096/ https://www.ncbi.nlm.nih.gov/pubmed/26784683 http://dx.doi.org/10.1016/j.vaccine.2015.12.021

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