Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the most common amino acid substitution activates the kinase two- to threefold. This has motivated the development of LRRK2...

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Detalles Bibliográficos
Autores principales: Steger, Martin, Tonelli, Francesca, Ito, Genta, Davies, Paul, Trost, Matthias, Vetter, Melanie, Wachter, Stefanie, Lorentzen, Esben, Duddy, Graham, Wilson, Stephen, Baptista, Marco AS, Fiske, Brian K, Fell, Matthew J, Morrow, John A, Reith, Alastair D, Alessi, Dario R, Mann, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769169/
https://www.ncbi.nlm.nih.gov/pubmed/26824392
http://dx.doi.org/10.7554/eLife.12813

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