Cargando…

Uncommon presentation of potential medication-related osteonecrosis of the jaw

BACKGROUND: This article presents a patient with potential atypical medication-related osteonecrosis of the jaw and reviews related literatures. CASE PRESENTATION: A 52-year-old male showed pain in the left buccal area and had numbness on the left lower lip area. He received medications having anti-...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Seong-Gon, Kweon, HaeYong, Lee, Suk-Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769240/
https://www.ncbi.nlm.nih.gov/pubmed/27026883
http://dx.doi.org/10.1186/s40064-016-1902-5
_version_ 1782418072661917696
author Kim, Seong-Gon
Kweon, HaeYong
Lee, Suk-Keun
author_facet Kim, Seong-Gon
Kweon, HaeYong
Lee, Suk-Keun
author_sort Kim, Seong-Gon
collection PubMed
description BACKGROUND: This article presents a patient with potential atypical medication-related osteonecrosis of the jaw and reviews related literatures. CASE PRESENTATION: A 52-year-old male showed pain in the left buccal area and had numbness on the left lower lip area. He received medications having anti-angiogenic effect for 4 years. He did not receive irradiation of the jaw regions. In histological view, most of the adipocytes were destroyed and disappeared in the scanty vascular marrow tissue, resulting in the replacement of the fatty necrosis with variable sized vacuolated empty spaces. In the immunohistochemistry analysis, the infiltrated macrophages into the marrow stromal tissue were strongly positive for lysozymes. These findings demonstrate that the presented osteonecrosis underwent a chronic and persistent granulomatous inflammatory reaction. CONCLUSIONS: We conclude that the present case might have been caused by anti-angiogenic drug abuse, affecting the reduction of the mandibular marrow vascularity and subsequently inducing fatty necrosis and an extensive osteolytic change of the mandible.
format Online
Article
Text
id pubmed-4769240
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-47692402016-03-29 Uncommon presentation of potential medication-related osteonecrosis of the jaw Kim, Seong-Gon Kweon, HaeYong Lee, Suk-Keun Springerplus Case Study BACKGROUND: This article presents a patient with potential atypical medication-related osteonecrosis of the jaw and reviews related literatures. CASE PRESENTATION: A 52-year-old male showed pain in the left buccal area and had numbness on the left lower lip area. He received medications having anti-angiogenic effect for 4 years. He did not receive irradiation of the jaw regions. In histological view, most of the adipocytes were destroyed and disappeared in the scanty vascular marrow tissue, resulting in the replacement of the fatty necrosis with variable sized vacuolated empty spaces. In the immunohistochemistry analysis, the infiltrated macrophages into the marrow stromal tissue were strongly positive for lysozymes. These findings demonstrate that the presented osteonecrosis underwent a chronic and persistent granulomatous inflammatory reaction. CONCLUSIONS: We conclude that the present case might have been caused by anti-angiogenic drug abuse, affecting the reduction of the mandibular marrow vascularity and subsequently inducing fatty necrosis and an extensive osteolytic change of the mandible. Springer International Publishing 2016-02-27 /pmc/articles/PMC4769240/ /pubmed/27026883 http://dx.doi.org/10.1186/s40064-016-1902-5 Text en © Kim et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Study
Kim, Seong-Gon
Kweon, HaeYong
Lee, Suk-Keun
Uncommon presentation of potential medication-related osteonecrosis of the jaw
title Uncommon presentation of potential medication-related osteonecrosis of the jaw
title_full Uncommon presentation of potential medication-related osteonecrosis of the jaw
title_fullStr Uncommon presentation of potential medication-related osteonecrosis of the jaw
title_full_unstemmed Uncommon presentation of potential medication-related osteonecrosis of the jaw
title_short Uncommon presentation of potential medication-related osteonecrosis of the jaw
title_sort uncommon presentation of potential medication-related osteonecrosis of the jaw
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769240/
https://www.ncbi.nlm.nih.gov/pubmed/27026883
http://dx.doi.org/10.1186/s40064-016-1902-5
work_keys_str_mv AT kimseonggon uncommonpresentationofpotentialmedicationrelatedosteonecrosisofthejaw
AT kweonhaeyong uncommonpresentationofpotentialmedicationrelatedosteonecrosisofthejaw
AT leesukkeun uncommonpresentationofpotentialmedicationrelatedosteonecrosisofthejaw