Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material

BACKGROUND: Targeted Next Generation Sequencing (NGS) offers a way to implement testing of multiple genetic aberrations in diagnostic pathology practice, which is necessary for personalized cancer treatment. However, no standards regarding input material have been defined. This study therefore aimed...

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Detalles Bibliográficos
Autores principales: de Leng, Wendy W. J., Gadellaa-van Hooijdonk, Christa G., Barendregt-Smouter, Françoise A. S., Koudijs, Marco J., Nijman, Ies, Hinrichs, John W. J., Cuppen, Edwin, van Lieshout, Stef, Loberg, Robert D., de Jonge, Maja, Voest, Emile E., de Weger, Roel A., Steeghs, Neeltje, Langenberg, Marlies H. G., Sleijfer, Stefan, Willems, Stefan M., Lolkema, Martijn P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769293/
https://www.ncbi.nlm.nih.gov/pubmed/26919633
http://dx.doi.org/10.1371/journal.pone.0149405

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