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Albumin-based drug delivery: harnessing nature to cure disease

The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand...

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Autores principales: Larsen, Maja Thim, Kuhlmann, Matthias, Hvam, Michael Lykke, Howard, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769556/
https://www.ncbi.nlm.nih.gov/pubmed/26925240
http://dx.doi.org/10.1186/s40591-016-0048-8
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author Larsen, Maja Thim
Kuhlmann, Matthias
Hvam, Michael Lykke
Howard, Kenneth A.
author_facet Larsen, Maja Thim
Kuhlmann, Matthias
Hvam, Michael Lykke
Howard, Kenneth A.
author_sort Larsen, Maja Thim
collection PubMed
description The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform.
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spelling pubmed-47695562016-02-28 Albumin-based drug delivery: harnessing nature to cure disease Larsen, Maja Thim Kuhlmann, Matthias Hvam, Michael Lykke Howard, Kenneth A. Mol Cell Ther Review The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform. BioMed Central 2016-02-27 /pmc/articles/PMC4769556/ /pubmed/26925240 http://dx.doi.org/10.1186/s40591-016-0048-8 Text en © Larsen et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Larsen, Maja Thim
Kuhlmann, Matthias
Hvam, Michael Lykke
Howard, Kenneth A.
Albumin-based drug delivery: harnessing nature to cure disease
title Albumin-based drug delivery: harnessing nature to cure disease
title_full Albumin-based drug delivery: harnessing nature to cure disease
title_fullStr Albumin-based drug delivery: harnessing nature to cure disease
title_full_unstemmed Albumin-based drug delivery: harnessing nature to cure disease
title_short Albumin-based drug delivery: harnessing nature to cure disease
title_sort albumin-based drug delivery: harnessing nature to cure disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769556/
https://www.ncbi.nlm.nih.gov/pubmed/26925240
http://dx.doi.org/10.1186/s40591-016-0048-8
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