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Albumin-based drug delivery: harnessing nature to cure disease
The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769556/ https://www.ncbi.nlm.nih.gov/pubmed/26925240 http://dx.doi.org/10.1186/s40591-016-0048-8 |
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author | Larsen, Maja Thim Kuhlmann, Matthias Hvam, Michael Lykke Howard, Kenneth A. |
author_facet | Larsen, Maja Thim Kuhlmann, Matthias Hvam, Michael Lykke Howard, Kenneth A. |
author_sort | Larsen, Maja Thim |
collection | PubMed |
description | The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform. |
format | Online Article Text |
id | pubmed-4769556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47695562016-02-28 Albumin-based drug delivery: harnessing nature to cure disease Larsen, Maja Thim Kuhlmann, Matthias Hvam, Michael Lykke Howard, Kenneth A. Mol Cell Ther Review The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor. Exploitation of these properties promotes albumin as an attractive candidate for half-life extension and targeted intracellular delivery of drugs attached by covalent conjugation, genetic fusions, association or ligand-mediated association. This review will give an overview of albumin-based products with focus on the natural biological properties and molecular interactions that can be harnessed for the design of a next-generation drug delivery platform. BioMed Central 2016-02-27 /pmc/articles/PMC4769556/ /pubmed/26925240 http://dx.doi.org/10.1186/s40591-016-0048-8 Text en © Larsen et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Larsen, Maja Thim Kuhlmann, Matthias Hvam, Michael Lykke Howard, Kenneth A. Albumin-based drug delivery: harnessing nature to cure disease |
title | Albumin-based drug delivery: harnessing nature to cure disease |
title_full | Albumin-based drug delivery: harnessing nature to cure disease |
title_fullStr | Albumin-based drug delivery: harnessing nature to cure disease |
title_full_unstemmed | Albumin-based drug delivery: harnessing nature to cure disease |
title_short | Albumin-based drug delivery: harnessing nature to cure disease |
title_sort | albumin-based drug delivery: harnessing nature to cure disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769556/ https://www.ncbi.nlm.nih.gov/pubmed/26925240 http://dx.doi.org/10.1186/s40591-016-0048-8 |
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