De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging

Fifteen to 20% of children with neurofibromatosis type 1 develop low-grade glial neoplasms. However, since neuroimaging is not routinely obtained until a child is clinically symptomatic, little is known about presymptomatic radiographic characteristics of gliomas in this at-risk population. Herein,...

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Autores principales: Zafar, Rabia, Hsiao, Esther Y., Botteron, Kelly N., McKinstry, Robert C., Gutmann, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769616/
https://www.ncbi.nlm.nih.gov/pubmed/26973730
http://dx.doi.org/10.1016/j.radcr.2015.12.008
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author Zafar, Rabia
Hsiao, Esther Y.
Botteron, Kelly N.
McKinstry, Robert C.
Gutmann, David H.
author_facet Zafar, Rabia
Hsiao, Esther Y.
Botteron, Kelly N.
McKinstry, Robert C.
Gutmann, David H.
author_sort Zafar, Rabia
collection PubMed
description Fifteen to 20% of children with neurofibromatosis type 1 develop low-grade glial neoplasms. However, since neuroimaging is not routinely obtained until a child is clinically symptomatic, little is known about presymptomatic radiographic characteristics of gliomas in this at-risk population. Herein, we describe a child with neurofibromatosis type 1 who initially had normal brain imaging before the development of multifocal gliomas. Comparison of these serial images demonstrated that brain tumors can arise de novo in children with this cancer predisposition syndrome, further underscoring the limited prognostic value of normal baseline magnetic resonance imaging.
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spelling pubmed-47696162016-03-11 De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging Zafar, Rabia Hsiao, Esther Y. Botteron, Kelly N. McKinstry, Robert C. Gutmann, David H. Radiol Case Rep Case Report Fifteen to 20% of children with neurofibromatosis type 1 develop low-grade glial neoplasms. However, since neuroimaging is not routinely obtained until a child is clinically symptomatic, little is known about presymptomatic radiographic characteristics of gliomas in this at-risk population. Herein, we describe a child with neurofibromatosis type 1 who initially had normal brain imaging before the development of multifocal gliomas. Comparison of these serial images demonstrated that brain tumors can arise de novo in children with this cancer predisposition syndrome, further underscoring the limited prognostic value of normal baseline magnetic resonance imaging. Elsevier 2016-02-02 /pmc/articles/PMC4769616/ /pubmed/26973730 http://dx.doi.org/10.1016/j.radcr.2015.12.008 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Zafar, Rabia
Hsiao, Esther Y.
Botteron, Kelly N.
McKinstry, Robert C.
Gutmann, David H.
De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging
title De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging
title_full De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging
title_fullStr De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging
title_full_unstemmed De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging
title_short De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging
title_sort de novo development of gliomas in a child with neurofibromatosis type 1, fragile x and previously normal brain magnetic resonance imaging
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769616/
https://www.ncbi.nlm.nih.gov/pubmed/26973730
http://dx.doi.org/10.1016/j.radcr.2015.12.008
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