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A Case of Relapsing Polychondritis Initiating with Unexplained Fever

Relapsing polychondritis (RP) is a rare autoimmune disease affecting the multiple organ system. Here, we describe a case of RP initially presenting with high fever. The patient was referred to our hospital for further examination of fever of unknown origin (FUO). On admission, the patient reported d...

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Autores principales: Hirayama, Kosuke, Iwanaga, Nozomi, Izumi, Yasumori, Yoshimura, Satoshi, Kurohama, Kazuhiro, Yamashita, Mai, Takahata, Taichi, Oku, Ryuta, Ito, Masahiro, Kawakami, Atsushi, Migita, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769741/
https://www.ncbi.nlm.nih.gov/pubmed/26981127
http://dx.doi.org/10.1155/2016/9462489
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author Hirayama, Kosuke
Iwanaga, Nozomi
Izumi, Yasumori
Yoshimura, Satoshi
Kurohama, Kazuhiro
Yamashita, Mai
Takahata, Taichi
Oku, Ryuta
Ito, Masahiro
Kawakami, Atsushi
Migita, Kiyoshi
author_facet Hirayama, Kosuke
Iwanaga, Nozomi
Izumi, Yasumori
Yoshimura, Satoshi
Kurohama, Kazuhiro
Yamashita, Mai
Takahata, Taichi
Oku, Ryuta
Ito, Masahiro
Kawakami, Atsushi
Migita, Kiyoshi
author_sort Hirayama, Kosuke
collection PubMed
description Relapsing polychondritis (RP) is a rare autoimmune disease affecting the multiple organ system. Here, we describe a case of RP initially presenting with high fever. The patient was referred to our hospital for further examination of fever of unknown origin (FUO). On admission, the patient reported dry cough in addition to fever. On physical examination, her red, swollen ears were noted, attributed on histology to inflammation with auricular perichondritis. She was diagnosed with RP and treated with oral prednisone (50 mg/day); her fever and auricular inflammation resolved. The patient no longer reported cough and body temperature returned to normal and the elevated levels of C-reactive protein (CRP) were normalized. In this case, identification of the origin of fever was a challenge because of unspecific symptoms; however, awareness of the systemic manifestations of RP may lead to the prompt diagnosis and therapeutic intervention.
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spelling pubmed-47697412016-03-15 A Case of Relapsing Polychondritis Initiating with Unexplained Fever Hirayama, Kosuke Iwanaga, Nozomi Izumi, Yasumori Yoshimura, Satoshi Kurohama, Kazuhiro Yamashita, Mai Takahata, Taichi Oku, Ryuta Ito, Masahiro Kawakami, Atsushi Migita, Kiyoshi Case Rep Med Case Report Relapsing polychondritis (RP) is a rare autoimmune disease affecting the multiple organ system. Here, we describe a case of RP initially presenting with high fever. The patient was referred to our hospital for further examination of fever of unknown origin (FUO). On admission, the patient reported dry cough in addition to fever. On physical examination, her red, swollen ears were noted, attributed on histology to inflammation with auricular perichondritis. She was diagnosed with RP and treated with oral prednisone (50 mg/day); her fever and auricular inflammation resolved. The patient no longer reported cough and body temperature returned to normal and the elevated levels of C-reactive protein (CRP) were normalized. In this case, identification of the origin of fever was a challenge because of unspecific symptoms; however, awareness of the systemic manifestations of RP may lead to the prompt diagnosis and therapeutic intervention. Hindawi Publishing Corporation 2016 2016-02-14 /pmc/articles/PMC4769741/ /pubmed/26981127 http://dx.doi.org/10.1155/2016/9462489 Text en Copyright © 2016 Kosuke Hirayama et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hirayama, Kosuke
Iwanaga, Nozomi
Izumi, Yasumori
Yoshimura, Satoshi
Kurohama, Kazuhiro
Yamashita, Mai
Takahata, Taichi
Oku, Ryuta
Ito, Masahiro
Kawakami, Atsushi
Migita, Kiyoshi
A Case of Relapsing Polychondritis Initiating with Unexplained Fever
title A Case of Relapsing Polychondritis Initiating with Unexplained Fever
title_full A Case of Relapsing Polychondritis Initiating with Unexplained Fever
title_fullStr A Case of Relapsing Polychondritis Initiating with Unexplained Fever
title_full_unstemmed A Case of Relapsing Polychondritis Initiating with Unexplained Fever
title_short A Case of Relapsing Polychondritis Initiating with Unexplained Fever
title_sort case of relapsing polychondritis initiating with unexplained fever
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769741/
https://www.ncbi.nlm.nih.gov/pubmed/26981127
http://dx.doi.org/10.1155/2016/9462489
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