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Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility

Glass-ceramic scaffolds containing Mg have shown recently the potential to enhance the proliferation, differentiation, and biomineralization of stem cells in vitro, property that makes them promising candidates for dental tissue regeneration. An additional property of a scaffold aimed at dental tiss...

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Autores principales: Theodorou, Georgios S., Kontonasaki, Eleana, Theocharidou, Anna, Bakopoulou, Athina, Bousnaki, Maria, Hadjichristou, Christina, Papachristou, Eleni, Papadopoulou, Lambrini, Kantiranis, Nikolaos A., Chrissafis, Konstantinos, Paraskevopoulos, Konstantinos M., Koidis, Petros T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769780/
https://www.ncbi.nlm.nih.gov/pubmed/26981124
http://dx.doi.org/10.1155/2016/3858301
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author Theodorou, Georgios S.
Kontonasaki, Eleana
Theocharidou, Anna
Bakopoulou, Athina
Bousnaki, Maria
Hadjichristou, Christina
Papachristou, Eleni
Papadopoulou, Lambrini
Kantiranis, Nikolaos A.
Chrissafis, Konstantinos
Paraskevopoulos, Konstantinos M.
Koidis, Petros T.
author_facet Theodorou, Georgios S.
Kontonasaki, Eleana
Theocharidou, Anna
Bakopoulou, Athina
Bousnaki, Maria
Hadjichristou, Christina
Papachristou, Eleni
Papadopoulou, Lambrini
Kantiranis, Nikolaos A.
Chrissafis, Konstantinos
Paraskevopoulos, Konstantinos M.
Koidis, Petros T.
author_sort Theodorou, Georgios S.
collection PubMed
description Glass-ceramic scaffolds containing Mg have shown recently the potential to enhance the proliferation, differentiation, and biomineralization of stem cells in vitro, property that makes them promising candidates for dental tissue regeneration. An additional property of a scaffold aimed at dental tissue regeneration is to protect the regeneration process against oral bacteria penetration. In this respect, novel bioactive scaffolds containing Mg(2+) and Cu(2+) or Zn(2+), ions known for their antimicrobial properties, were synthesized by the foam replica technique and tested regarding their bioactive response in SBF, mechanical properties, degradation, and porosity. Finally their ability to support the attachment and long-term proliferation of Dental Pulp Stem Cells (DPSCs) was also evaluated. The results showed that conversely to their bioactive response in SBF solution, Zn-doped scaffolds proved to respond adequately regarding their mechanical strength and to be efficient regarding their biological response, in comparison to Cu-doped scaffolds, which makes them promising candidates for targeted dental stem cell odontogenic differentiation and calcified dental tissue engineering.
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spelling pubmed-47697802016-03-15 Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility Theodorou, Georgios S. Kontonasaki, Eleana Theocharidou, Anna Bakopoulou, Athina Bousnaki, Maria Hadjichristou, Christina Papachristou, Eleni Papadopoulou, Lambrini Kantiranis, Nikolaos A. Chrissafis, Konstantinos Paraskevopoulos, Konstantinos M. Koidis, Petros T. Int J Biomater Research Article Glass-ceramic scaffolds containing Mg have shown recently the potential to enhance the proliferation, differentiation, and biomineralization of stem cells in vitro, property that makes them promising candidates for dental tissue regeneration. An additional property of a scaffold aimed at dental tissue regeneration is to protect the regeneration process against oral bacteria penetration. In this respect, novel bioactive scaffolds containing Mg(2+) and Cu(2+) or Zn(2+), ions known for their antimicrobial properties, were synthesized by the foam replica technique and tested regarding their bioactive response in SBF, mechanical properties, degradation, and porosity. Finally their ability to support the attachment and long-term proliferation of Dental Pulp Stem Cells (DPSCs) was also evaluated. The results showed that conversely to their bioactive response in SBF solution, Zn-doped scaffolds proved to respond adequately regarding their mechanical strength and to be efficient regarding their biological response, in comparison to Cu-doped scaffolds, which makes them promising candidates for targeted dental stem cell odontogenic differentiation and calcified dental tissue engineering. Hindawi Publishing Corporation 2016 2016-02-14 /pmc/articles/PMC4769780/ /pubmed/26981124 http://dx.doi.org/10.1155/2016/3858301 Text en Copyright © 2016 Georgios S. Theodorou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Theodorou, Georgios S.
Kontonasaki, Eleana
Theocharidou, Anna
Bakopoulou, Athina
Bousnaki, Maria
Hadjichristou, Christina
Papachristou, Eleni
Papadopoulou, Lambrini
Kantiranis, Nikolaos A.
Chrissafis, Konstantinos
Paraskevopoulos, Konstantinos M.
Koidis, Petros T.
Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility
title Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility
title_full Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility
title_fullStr Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility
title_full_unstemmed Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility
title_short Sol-Gel Derived Mg-Based Ceramic Scaffolds Doped with Zinc or Copper Ions: Preliminary Results on Their Synthesis, Characterization, and Biocompatibility
title_sort sol-gel derived mg-based ceramic scaffolds doped with zinc or copper ions: preliminary results on their synthesis, characterization, and biocompatibility
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769780/
https://www.ncbi.nlm.nih.gov/pubmed/26981124
http://dx.doi.org/10.1155/2016/3858301
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