Emerging roles of Nrf2 signal in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) causes considerable mortality in the world. Owing to molecular biological progress, treatments in adenocarcinoma have evolved revolutionarily while those in squamous lung cancer remain unsatisfied. Recent studies revealed high-frequency alteration of Kelch-like ECH...

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Autores principales: Tian, Yijun, Liu, Qian, He, Xuelian, Yuan, Xun, Chen, Yuan, Chu, Qian, Wu, Kongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769825/
https://www.ncbi.nlm.nih.gov/pubmed/26922479
http://dx.doi.org/10.1186/s13045-016-0246-5
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author Tian, Yijun
Liu, Qian
He, Xuelian
Yuan, Xun
Chen, Yuan
Chu, Qian
Wu, Kongming
author_facet Tian, Yijun
Liu, Qian
He, Xuelian
Yuan, Xun
Chen, Yuan
Chu, Qian
Wu, Kongming
author_sort Tian, Yijun
collection PubMed
description Non-small cell lung cancer (NSCLC) causes considerable mortality in the world. Owing to molecular biological progress, treatments in adenocarcinoma have evolved revolutionarily while those in squamous lung cancer remain unsatisfied. Recent studies revealed high-frequency alteration of Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-like factor 2 (Keap1/Nrf2) pathway within squamous lung cancer, attracting researchers to focus on this particular pathway. In NSCLC patients, deregulated Nrf2 signal is recognized as a common feature at both DNA and protein level. Emerging associations between Nrf2 and other pathways have been elucidated. MicroRNA was also implicated in the regulation of Nrf2. Agents activating or antagonizing Nrf2 showed an effect in preclinical researches, reflecting different effects of Nrf2 during tumor initiation and progression. Prognostic evaluation demonstrated a negative impact of Nrf2 signal on NSCLC patients’ survival. Considering the importance of Nrf2 signal in NSCLC, further studies are required in the future.
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spelling pubmed-47698252016-02-29 Emerging roles of Nrf2 signal in non-small cell lung cancer Tian, Yijun Liu, Qian He, Xuelian Yuan, Xun Chen, Yuan Chu, Qian Wu, Kongming J Hematol Oncol Review Non-small cell lung cancer (NSCLC) causes considerable mortality in the world. Owing to molecular biological progress, treatments in adenocarcinoma have evolved revolutionarily while those in squamous lung cancer remain unsatisfied. Recent studies revealed high-frequency alteration of Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-like factor 2 (Keap1/Nrf2) pathway within squamous lung cancer, attracting researchers to focus on this particular pathway. In NSCLC patients, deregulated Nrf2 signal is recognized as a common feature at both DNA and protein level. Emerging associations between Nrf2 and other pathways have been elucidated. MicroRNA was also implicated in the regulation of Nrf2. Agents activating or antagonizing Nrf2 showed an effect in preclinical researches, reflecting different effects of Nrf2 during tumor initiation and progression. Prognostic evaluation demonstrated a negative impact of Nrf2 signal on NSCLC patients’ survival. Considering the importance of Nrf2 signal in NSCLC, further studies are required in the future. BioMed Central 2016-02-27 /pmc/articles/PMC4769825/ /pubmed/26922479 http://dx.doi.org/10.1186/s13045-016-0246-5 Text en © Tian et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Tian, Yijun
Liu, Qian
He, Xuelian
Yuan, Xun
Chen, Yuan
Chu, Qian
Wu, Kongming
Emerging roles of Nrf2 signal in non-small cell lung cancer
title Emerging roles of Nrf2 signal in non-small cell lung cancer
title_full Emerging roles of Nrf2 signal in non-small cell lung cancer
title_fullStr Emerging roles of Nrf2 signal in non-small cell lung cancer
title_full_unstemmed Emerging roles of Nrf2 signal in non-small cell lung cancer
title_short Emerging roles of Nrf2 signal in non-small cell lung cancer
title_sort emerging roles of nrf2 signal in non-small cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769825/
https://www.ncbi.nlm.nih.gov/pubmed/26922479
http://dx.doi.org/10.1186/s13045-016-0246-5
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