Targeted alignment and end repair elimination increase alignment and methylation measure accuracy for reduced representation bisulfite sequencing data

BACKGROUND: DNA methylation is an important epigenetic modification involved in many biological processes. Reduced representation bisulfite sequencing (RRBS) is a cost-effective method for studying DNA methylation at single base resolution. Although several tools are available for RRBS data processi...

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Detalles Bibliográficos
Autores principales: Baheti, Saurabh, Kanwar, Rahul, Goelzenleuchter, Meike, Kocher, Jean-Pierre A., Beutler, Andreas S., Sun, Zhifu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769831/
https://www.ncbi.nlm.nih.gov/pubmed/26922377
http://dx.doi.org/10.1186/s12864-016-2494-8

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