Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

VRC01-class broadly neutralizing HIV-1 antibodies protect animals from experimental infection and could contribute to an effective vaccine response. Their predicted germline forms (gl) bind Env inefficiently, which may explain why they are not elicited by HIV-1 Env-immunization. Here we show that an...

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Detalles Bibliográficos
Autores principales: McGuire, Andrew T., Gray, Matthew D., Dosenovic, Pia, Gitlin, Alexander D., Freund, Natalia T., Petersen, John, Correnti, Colin, Johnsen, William, Kegel, Robert, Stuart, Andrew B., Glenn, Jolene, Seaman, Michael S., Schief, William R., Strong, Roland K., Nussenzweig, Michel C., Stamatatos, Leonidas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770077/
https://www.ncbi.nlm.nih.gov/pubmed/26907590
http://dx.doi.org/10.1038/ncomms10618

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