Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

Treatment for heart disease, the leading cause of death in the world, has progressed little for several decades. Here we develop a protein engineering approach to directly tune in vivo cardiac contractility by tailoring the ability of the heart to respond to the Ca(2+) signal. Promisingly, our smart...

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Detalles Bibliográficos
Autores principales: Shettigar, Vikram, Zhang, Bo, Little, Sean C., Salhi, Hussam E., Hansen, Brian J., Li, Ning, Zhang, Jianchao, Roof, Steve R., Ho, Hsiang-Ting, Brunello, Lucia, Lerch, Jessica K., Weisleder, Noah, Fedorov, Vadim V., Accornero, Federica, Rafael-Fortney, Jill A., Gyorke, Sandor, Janssen, Paul M. L., Biesiadecki, Brandon J., Ziolo, Mark T., Davis, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770086/
https://www.ncbi.nlm.nih.gov/pubmed/26908229
http://dx.doi.org/10.1038/ncomms10794

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