Cargando…

Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination

Cell-penetrating peptides (CPPs) are short amino acids that have been widely used to deliver macromolecules such as proteins, peptides, DNA, or RNA, to control cellular behavior for therapeutic purposes. CPPs have been used to treat immunological diseases through the delivery of immune modulatory mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Sangho, Koo, Ja-Hyun, Choi, Je-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770098/
https://www.ncbi.nlm.nih.gov/pubmed/26937230
http://dx.doi.org/10.4110/in.2016.16.1.33
_version_ 1782418198278176768
author Lim, Sangho
Koo, Ja-Hyun
Choi, Je-Min
author_facet Lim, Sangho
Koo, Ja-Hyun
Choi, Je-Min
author_sort Lim, Sangho
collection PubMed
description Cell-penetrating peptides (CPPs) are short amino acids that have been widely used to deliver macromolecules such as proteins, peptides, DNA, or RNA, to control cellular behavior for therapeutic purposes. CPPs have been used to treat immunological diseases through the delivery of immune modulatory molecules in vivo. Their intracellular delivery efficiency is highly synergistic with the cellular characteristics of the dendritic cells (DCs), which actively uptake foreign antigens. DC-based vaccines are primarily generated by pulsing DCs ex vivo with various immunomodulatory antigens. CPP conjugation to antigens would increase DC uptake as well as antigen processing and presentation on both MHC class II and MHC class I molecules, leading to antigen specific CD4(+) and CD8(+) T cell responses. CPP-antigen based DC vaccination is considered a promising tool for cancer immunotherapy due to the enhanced CTL response. In this review, we discuss the various applications of CPPs in immune modulation and DC vaccination, and highlight the advantages and limitations of the current CPP-based DC vaccination.
format Online
Article
Text
id pubmed-4770098
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher The Korean Association of Immunologists
record_format MEDLINE/PubMed
spelling pubmed-47700982016-03-02 Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination Lim, Sangho Koo, Ja-Hyun Choi, Je-Min Immune Netw Review Article Cell-penetrating peptides (CPPs) are short amino acids that have been widely used to deliver macromolecules such as proteins, peptides, DNA, or RNA, to control cellular behavior for therapeutic purposes. CPPs have been used to treat immunological diseases through the delivery of immune modulatory molecules in vivo. Their intracellular delivery efficiency is highly synergistic with the cellular characteristics of the dendritic cells (DCs), which actively uptake foreign antigens. DC-based vaccines are primarily generated by pulsing DCs ex vivo with various immunomodulatory antigens. CPP conjugation to antigens would increase DC uptake as well as antigen processing and presentation on both MHC class II and MHC class I molecules, leading to antigen specific CD4(+) and CD8(+) T cell responses. CPP-antigen based DC vaccination is considered a promising tool for cancer immunotherapy due to the enhanced CTL response. In this review, we discuss the various applications of CPPs in immune modulation and DC vaccination, and highlight the advantages and limitations of the current CPP-based DC vaccination. The Korean Association of Immunologists 2016-02 2016-02-25 /pmc/articles/PMC4770098/ /pubmed/26937230 http://dx.doi.org/10.4110/in.2016.16.1.33 Text en Copyright © 2016 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lim, Sangho
Koo, Ja-Hyun
Choi, Je-Min
Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination
title Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination
title_full Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination
title_fullStr Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination
title_full_unstemmed Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination
title_short Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination
title_sort use of cell-penetrating peptides in dendritic cell-based vaccination
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770098/
https://www.ncbi.nlm.nih.gov/pubmed/26937230
http://dx.doi.org/10.4110/in.2016.16.1.33
work_keys_str_mv AT limsangho useofcellpenetratingpeptidesindendriticcellbasedvaccination
AT koojahyun useofcellpenetratingpeptidesindendriticcellbasedvaccination
AT choijemin useofcellpenetratingpeptidesindendriticcellbasedvaccination