Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity

We compared the acute toxicity of nanosilica and polyacrylate/nanosilica instillation in Wistar rats (n = 60). Exposure to nanosilica and polyacrylate/nanosilica showed a 30% mortality rate. When compared with saline-treated rats, animals in both exposure groups exhibited a significant reduction of...

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Detalles Bibliográficos
Autores principales: Niu, Ying-Mei, Zhu, Xiao-Li, Chang, Bing, Tong, Zhao-Hui, Cao, Wen, Qiao, Pei-Huan, Zhang, Lin-Yuan, Zhao, Jing, Song, Yu-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770131/
https://www.ncbi.nlm.nih.gov/pubmed/26981538
http://dx.doi.org/10.1155/2016/9353275
Descripción
Sumario:We compared the acute toxicity of nanosilica and polyacrylate/nanosilica instillation in Wistar rats (n = 60). Exposure to nanosilica and polyacrylate/nanosilica showed a 30% mortality rate. When compared with saline-treated rats, animals in both exposure groups exhibited a significant reduction of PO(2) (P < 0.05) at both 24 and 72 hr. after exposure. Both exposure groups exhibited a significant reduction of neutrophils in arterial blood compared to saline controls (P < 0.05) 24 hr. after exposure. The levels of blood ALT and LDH in exposed groups were found to be significantly increased (P < 0.05) 24 hr. following exposure. The exposed groups exhibited various degrees of pleural effusion and pericardial effusion. Our findings indicated respiratory exposure to polyacrylate/nanosilica and nanosilica is likely to cause multiple organ toxicity.

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