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Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity

We compared the acute toxicity of nanosilica and polyacrylate/nanosilica instillation in Wistar rats (n = 60). Exposure to nanosilica and polyacrylate/nanosilica showed a 30% mortality rate. When compared with saline-treated rats, animals in both exposure groups exhibited a significant reduction of...

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Autores principales: Niu, Ying-Mei, Zhu, Xiao-Li, Chang, Bing, Tong, Zhao-Hui, Cao, Wen, Qiao, Pei-Huan, Zhang, Lin-Yuan, Zhao, Jing, Song, Yu-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770131/
https://www.ncbi.nlm.nih.gov/pubmed/26981538
http://dx.doi.org/10.1155/2016/9353275
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author Niu, Ying-Mei
Zhu, Xiao-Li
Chang, Bing
Tong, Zhao-Hui
Cao, Wen
Qiao, Pei-Huan
Zhang, Lin-Yuan
Zhao, Jing
Song, Yu-Guo
author_facet Niu, Ying-Mei
Zhu, Xiao-Li
Chang, Bing
Tong, Zhao-Hui
Cao, Wen
Qiao, Pei-Huan
Zhang, Lin-Yuan
Zhao, Jing
Song, Yu-Guo
author_sort Niu, Ying-Mei
collection PubMed
description We compared the acute toxicity of nanosilica and polyacrylate/nanosilica instillation in Wistar rats (n = 60). Exposure to nanosilica and polyacrylate/nanosilica showed a 30% mortality rate. When compared with saline-treated rats, animals in both exposure groups exhibited a significant reduction of PO(2) (P < 0.05) at both 24 and 72 hr. after exposure. Both exposure groups exhibited a significant reduction of neutrophils in arterial blood compared to saline controls (P < 0.05) 24 hr. after exposure. The levels of blood ALT and LDH in exposed groups were found to be significantly increased (P < 0.05) 24 hr. following exposure. The exposed groups exhibited various degrees of pleural effusion and pericardial effusion. Our findings indicated respiratory exposure to polyacrylate/nanosilica and nanosilica is likely to cause multiple organ toxicity.
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spelling pubmed-47701312016-03-15 Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity Niu, Ying-Mei Zhu, Xiao-Li Chang, Bing Tong, Zhao-Hui Cao, Wen Qiao, Pei-Huan Zhang, Lin-Yuan Zhao, Jing Song, Yu-Guo Biomed Res Int Research Article We compared the acute toxicity of nanosilica and polyacrylate/nanosilica instillation in Wistar rats (n = 60). Exposure to nanosilica and polyacrylate/nanosilica showed a 30% mortality rate. When compared with saline-treated rats, animals in both exposure groups exhibited a significant reduction of PO(2) (P < 0.05) at both 24 and 72 hr. after exposure. Both exposure groups exhibited a significant reduction of neutrophils in arterial blood compared to saline controls (P < 0.05) 24 hr. after exposure. The levels of blood ALT and LDH in exposed groups were found to be significantly increased (P < 0.05) 24 hr. following exposure. The exposed groups exhibited various degrees of pleural effusion and pericardial effusion. Our findings indicated respiratory exposure to polyacrylate/nanosilica and nanosilica is likely to cause multiple organ toxicity. Hindawi Publishing Corporation 2016 2016-02-15 /pmc/articles/PMC4770131/ /pubmed/26981538 http://dx.doi.org/10.1155/2016/9353275 Text en Copyright © 2016 Ying-Mei Niu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Niu, Ying-Mei
Zhu, Xiao-Li
Chang, Bing
Tong, Zhao-Hui
Cao, Wen
Qiao, Pei-Huan
Zhang, Lin-Yuan
Zhao, Jing
Song, Yu-Guo
Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity
title Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity
title_full Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity
title_fullStr Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity
title_full_unstemmed Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity
title_short Nanosilica and Polyacrylate/Nanosilica: A Comparative Study of Acute Toxicity
title_sort nanosilica and polyacrylate/nanosilica: a comparative study of acute toxicity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770131/
https://www.ncbi.nlm.nih.gov/pubmed/26981538
http://dx.doi.org/10.1155/2016/9353275
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