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Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression

Mammalian DNA (cytosine-5) methyltransferase 1 (DNMT1) is essential for maintenance methylation. Phosphorylation of Ser143 (pSer143) stabilizes DNMT1 during DNA replication. Here, we show 14-3-3 is a reader protein of DNMT1pSer143. In mammalian cells 14-3-3 colocalizes and binds DNMT1pSer143 post-DN...

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Detalles Bibliográficos
Autores principales:	Estève, Pierre-Olivier, Zhang, Guoqiang, Ponnaluri, V.K. Chaithanya, Deepti, Kanneganti, Chin, Hang Gyeong, Dai, Nan, Sagum, Cari, Black, Karynne, Corrêa, Ivan R., Bedford, Mark T., Cheng, Xiaodong, Pradhan, Sriharsa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770214/ https://www.ncbi.nlm.nih.gov/pubmed/26553800 http://dx.doi.org/10.1093/nar/gkv1162

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