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Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression
Mammalian DNA (cytosine-5) methyltransferase 1 (DNMT1) is essential for maintenance methylation. Phosphorylation of Ser143 (pSer143) stabilizes DNMT1 during DNA replication. Here, we show 14-3-3 is a reader protein of DNMT1pSer143. In mammalian cells 14-3-3 colocalizes and binds DNMT1pSer143 post-DN...
Autores principales: | Estève, Pierre-Olivier, Zhang, Guoqiang, Ponnaluri, V.K. Chaithanya, Deepti, Kanneganti, Chin, Hang Gyeong, Dai, Nan, Sagum, Cari, Black, Karynne, Corrêa, Ivan R., Bedford, Mark T., Cheng, Xiaodong, Pradhan, Sriharsa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770214/ https://www.ncbi.nlm.nih.gov/pubmed/26553800 http://dx.doi.org/10.1093/nar/gkv1162 |
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