Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools

The absolute and relative concentrations of the four dNTPs are key determinants of DNA replication fidelity, yet the consequences of altered dNTP pools on replication fidelity have not previously been investigated on a genome-wide scale. Here, we use deep sequencing to determine the types, rates and...

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Detalles Bibliográficos
Autores principales: Watt, Danielle L., Buckland, Robert J., Lujan, Scott A., Kunkel, Thomas A., Chabes, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770217/
https://www.ncbi.nlm.nih.gov/pubmed/26609135
http://dx.doi.org/10.1093/nar/gkv1298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770217/
https://www.ncbi.nlm.nih.gov/pubmed/26609135
http://dx.doi.org/10.1093/nar/gkv1298

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