The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair

Ku70-binding protein 5 (Kub5)-Hera (K-H)/RPRD1B maintains genetic integrity by concomitantly minimizing persistent R-loops and promoting repair of DNA double strand breaks (DSBs). We used tandem affinity purification-mass spectrometry, co-immunoprecipitation and gel-filtration chromatography to defi...

Descripción completa

Detalles Bibliográficos
Autores principales: Patidar, Praveen L., Motea, Edward A., Fattah, Farjana J., Zhou, Yunyun, Morales, Julio C., Xie, Yang, Garner, Harold R., Boothman, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770225/
https://www.ncbi.nlm.nih.gov/pubmed/26819409
http://dx.doi.org/10.1093/nar/gkv1492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770225/
https://www.ncbi.nlm.nih.gov/pubmed/26819409
http://dx.doi.org/10.1093/nar/gkv1492

Ejemplares similares