Cargando…

The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair

Ku70-binding protein 5 (Kub5)-Hera (K-H)/RPRD1B maintains genetic integrity by concomitantly minimizing persistent R-loops and promoting repair of DNA double strand breaks (DSBs). We used tandem affinity purification-mass spectrometry, co-immunoprecipitation and gel-filtration chromatography to defi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patidar, Praveen L., Motea, Edward A., Fattah, Farjana J., Zhou, Yunyun, Morales, Julio C., Xie, Yang, Garner, Harold R., Boothman, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770225/ https://www.ncbi.nlm.nih.gov/pubmed/26819409 http://dx.doi.org/10.1093/nar/gkv1492

Ejemplares similares

Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair
por: Morales, Julio C., et al.
Publicado: (2014)

Hydrolytic function of Exo1 in mammalian mismatch repair
por: Shao, Hongbing, et al.
Publicado: (2014)

SLX4 dampens MutSα-dependent mismatch repair
por: Guervilly, Jean-Hugues, et al.
Publicado: (2022)

XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition
por: Patidar, Praveen L., et al.
Publicado: (2020)

Mechanism of formation of a toroid around DNA by the mismatch sensor protein
por: Nirwal, Shivlee, et al.
Publicado: (2018)

Spatial coupling between DNA replication and mismatch repair in Caulobacter crescentus
por: Chai, Tiancong, et al.
Publicado: (2021)

An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation
por: Grin, Inga, et al.
Publicado: (2016)

Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair
por: Hermans, Nicolaas, et al.
Publicado: (2016)

Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS
por: LeBlanc, Sharonda J, et al.
Publicado: (2018)

DNA mismatch repair protects the genome from oxygen-induced replicative mutagenesis
por: Lózsa, Rita, et al.
Publicado: (2023)

Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks
por: Zhao, Junhua, et al.
Publicado: (2009)

Stoichiometry of MutS and MutL at unrepaired mismatches in vivo suggests a mechanism of repair
por: Elez, Marina, et al.
Publicado: (2012)

Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity
por: Kothandapani, Anbarasi, et al.
Publicado: (2013)

Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects
por: Lujan, Scott A., et al.
Publicado: (2015)

Handcuffing intrinsically disordered regions in Mlh1–Pms1 disrupts mismatch repair
por: Furman, Christopher M, et al.
Publicado: (2021)

Preferential CEBP binding to T:G mismatches and increased C-to-T human somatic mutations
por: Yang, Jie, et al.
Publicado: (2021)

Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA
por: Cristóvão, Michele, et al.
Publicado: (2012)

Mismatch recognition and subsequent processing have distinct effects on mitotic recombination intermediates and outcomes in yeast
por: Hum, Yee Fang, et al.
Publicado: (2019)

Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex
por: Paul Solomon Devakumar, Lovely Jael, et al.
Publicado: (2019)

Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1
por: He, Wei, et al.
Publicado: (2008)

Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation
por: Groothuizen, Flora S., et al.
Publicado: (2013)

Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding
por: Bruekner, Susanne R, et al.
Publicado: (2023)

Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair
por: Shahi, Ankita, et al.
Publicado: (2011)

Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation
por: Lv, Lingna, et al.
Publicado: (2013)

The ligation of pol β mismatch insertion products governs the formation of promutagenic base excision DNA repair intermediates
por: Çağlayan, Melike
Publicado: (2020)

Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex
por: Kim, Yoori, et al.
Publicado: (2019)

Bacterial EndoMS/NucS acts as a clamp-mediated mismatch endonuclease to prevent asymmetric accumulation of replication errors
por: Takemoto, Norihiko, et al.
Publicado: (2018)

The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension
por: Witte, Scott J, et al.
Publicado: (2023)

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair
por: Mardenborough, Yannicka S N, et al.
Publicado: (2019)

DNA damage alters DNA polymerase δ to a form that exhibits increased discrimination against modified template bases and mismatched primers
por: Meng, Xiao, et al.
Publicado: (2009)

Mph1 requires mismatch repair-independent and -dependent functions of MutSα to regulate crossover formation during homologous recombination repair
por: Tay, Ye Dee, et al.
Publicado: (2010)

Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands
por: Talhaoui, Ibtissam, et al.
Publicado: (2014)

Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro
por: Liu, Dekang, et al.
Publicado: (2017)

7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases
por: Talhaoui, Ibtissam, et al.
Publicado: (2013)

DNA mismatch repair and oligonucleotide end-protection promote base-pair substitution distal from a CRISPR/Cas9-induced DNA break
por: Harmsen, Tim, et al.
Publicado: (2018)

Enhanced spontaneous DNA twisting/bending fluctuations unveiled by fluorescence lifetime distributions promote mismatch recognition by the Rad4 nucleotide excision repair complex
por: Chakraborty, Sagnik, et al.
Publicado: (2018)

A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation
por: Wolf, Karla, et al.
Publicado: (2023)

LKB1 preserves genome integrity by stimulating BRCA1 expression
por: Gupta, Romi, et al.
Publicado: (2015)

Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway
por: Grippon, Seden, et al.
Publicado: (2011)

RecJ-like protein from Pyrococcus furiosus has 3′–5′ exonuclease activity on RNA: implications for proofreading of 3′-mismatched RNA primers in DNA replication
por: Yuan, Hui, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7612mbb81gjk13p34o6cgjbe1t