A higher-order entity formed by the flexible assembly of RAP1 with TRF2

Telomere integrity is essential to maintain genome stability, and telomeric dysfunctions are associated with cancer and aging pathologies. In human, the shelterin complex binds TTAGGG DNA repeats and provides capping to chromosome ends. Within shelterin, RAP1 is recruited through its interaction wit...

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Detalles Bibliográficos
Autores principales: Gaullier, Guillaume, Miron, Simona, Pisano, Sabrina, Buisson, Rémi, Le Bihan, Yann-Vaï, Tellier-Lebègue, Carine, Messaoud, Wala, Roblin, Pierre, Guimarães, Beatriz G., Thai, Robert, Giraud-Panis, Marie-Josèphe, Gilson, Eric, Le Du, Marie-Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770236/
https://www.ncbi.nlm.nih.gov/pubmed/26748096
http://dx.doi.org/10.1093/nar/gkv1531

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