Progress and prospects of long noncoding RNAs in lipid homeostasis

BACKGROUND: Long noncoding RNAs (lncRNAs) are a novel group of universally present, non-coding RNAs (>200 nt) that are increasingly recognized as key regulators of many physiological and pathological processes. SCOPE OF REVIEW: Recent publications have shown that lncRNAs influence lipid homeostas...

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Detalles Bibliográficos
Autor principal: Chen, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770261/
https://www.ncbi.nlm.nih.gov/pubmed/26977388
http://dx.doi.org/10.1016/j.molmet.2015.12.003
Descripción
Sumario:BACKGROUND: Long noncoding RNAs (lncRNAs) are a novel group of universally present, non-coding RNAs (>200 nt) that are increasingly recognized as key regulators of many physiological and pathological processes. SCOPE OF REVIEW: Recent publications have shown that lncRNAs influence lipid homeostasis by controlling lipid metabolism in the liver and by regulating adipogenesis. lncRNAs control lipid metabolism-related gene expression by either base-pairing with RNA and DNA or by binding to proteins. MAJOR CONCLUSIONS: The recent advances and future prospects in understanding the roles of lncRNAs in lipid homeostasis are discussed.

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