Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes

OBJECTIVE: Although glucagon-secreting α-cells and insulin-secreting β-cells have opposing functions in regulating plasma glucose levels, the two cell types share a common developmental origin and exhibit overlapping transcriptomes and epigenomes. Notably, destruction of β-cells can stimulate repopu...

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Detalles Bibliográficos
Autores principales: Ackermann, Amanda M., Wang, Zhiping, Schug, Jonathan, Naji, Ali, Kaestner, Klaus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770267/
https://www.ncbi.nlm.nih.gov/pubmed/26977395
http://dx.doi.org/10.1016/j.molmet.2016.01.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770267/
https://www.ncbi.nlm.nih.gov/pubmed/26977395
http://dx.doi.org/10.1016/j.molmet.2016.01.002

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