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High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

OBJECTIVES: Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring. METHODS: F0-male rats fed either HFD or chow diet...

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Detalles Bibliográficos
Autores principales:	de Castro Barbosa, Thais, Ingerslev, Lars R., Alm, Petter S., Versteyhe, Soetkin, Massart, Julie, Rasmussen, Morten, Donkin, Ida, Sjögren, Rasmus, Mudry, Jonathan M., Vetterli, Laurène, Gupta, Shashank, Krook, Anna, Zierath, Juleen R., Barrès, Romain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770269/ https://www.ncbi.nlm.nih.gov/pubmed/26977389 http://dx.doi.org/10.1016/j.molmet.2015.12.002

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