Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

[Image: see text] TRIM24 is a transcriptional regulator as well as an E3 ubiquitin ligase. It is overexpressed in diverse tumors, and high expression levels have been linked to poor prognosis in breast cancer patients. TRIM24 contains a PHD/bromodomain offering the opportunity to develop protein int...

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Detalles Bibliográficos
Autores principales: Bennett, James, Fedorov, Oleg, Tallant, Cynthia, Monteiro, Octovia, Meier, Julia, Gamble, Vicky, Savitsky, Pavel, Nunez-Alonso, Graciela A, Haendler, Bernard, Rogers, Catherine, Brennan, Paul E., Müller, Susanne, Knapp, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770308/
https://www.ncbi.nlm.nih.gov/pubmed/25974391
http://dx.doi.org/10.1021/acs.jmedchem.5b00458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770308/
https://www.ncbi.nlm.nih.gov/pubmed/25974391
http://dx.doi.org/10.1021/acs.jmedchem.5b00458

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