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Retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study

The goal of this study was to evaluate the risk of developing acute myocardial infarction (AMI) following retinal vein occlusion (RVO). A retrospective cohort study was performed from the National Health Insurance Service and comprised 1,025,340 random subjects who were followed from 2002 to 2013. P...

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Autores principales: Rim, Tyler Hyungtaek, Han, John Seungsoo, Oh, Jaewon, Kim, Dong Wook, Kang, Seok-Min, Chung, Eun Jee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770309/
https://www.ncbi.nlm.nih.gov/pubmed/26924150
http://dx.doi.org/10.1038/srep22351
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author Rim, Tyler Hyungtaek
Han, John Seungsoo
Oh, Jaewon
Kim, Dong Wook
Kang, Seok-Min
Chung, Eun Jee
author_facet Rim, Tyler Hyungtaek
Han, John Seungsoo
Oh, Jaewon
Kim, Dong Wook
Kang, Seok-Min
Chung, Eun Jee
author_sort Rim, Tyler Hyungtaek
collection PubMed
description The goal of this study was to evaluate the risk of developing acute myocardial infarction (AMI) following retinal vein occlusion (RVO). A retrospective cohort study was performed from the National Health Insurance Service and comprised 1,025,340 random subjects who were followed from 2002 to 2013. Patients with RVO in 2002 were excluded. The RVO group was composed of patients who received an initial RVO diagnosis between January 2003 and December 2007 (n = 1677). The comparison group was selected (five patients per RVO patient; n = 8367) using propensity score matching according to sociodemographic factors and the year of enrolment. Each patient was tracked until 2013. The Cox proportional hazard regression model was used. AMI developed in 7.6% of the RVO group and 5.3% of the comparison group (p < 0.001) for 7.7 median follow-up periods. RVO increased the risk of AMI development [hazard ratio (HR) = 1.25; 95% Confidence Interval (CI) 1.02 to 1.52]. In the subgroup analysis, RVO patients aged <65 years and the males within this age group had an adjusted HR of 1.47 (95% CI 1.10 to 1.98) and an adjusted HR of 2.00 (95% CI 1.38 to 2.91) for AMI development, respectively. RVO was significantly associated with AMI development.
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spelling pubmed-47703092016-03-07 Retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study Rim, Tyler Hyungtaek Han, John Seungsoo Oh, Jaewon Kim, Dong Wook Kang, Seok-Min Chung, Eun Jee Sci Rep Article The goal of this study was to evaluate the risk of developing acute myocardial infarction (AMI) following retinal vein occlusion (RVO). A retrospective cohort study was performed from the National Health Insurance Service and comprised 1,025,340 random subjects who were followed from 2002 to 2013. Patients with RVO in 2002 were excluded. The RVO group was composed of patients who received an initial RVO diagnosis between January 2003 and December 2007 (n = 1677). The comparison group was selected (five patients per RVO patient; n = 8367) using propensity score matching according to sociodemographic factors and the year of enrolment. Each patient was tracked until 2013. The Cox proportional hazard regression model was used. AMI developed in 7.6% of the RVO group and 5.3% of the comparison group (p < 0.001) for 7.7 median follow-up periods. RVO increased the risk of AMI development [hazard ratio (HR) = 1.25; 95% Confidence Interval (CI) 1.02 to 1.52]. In the subgroup analysis, RVO patients aged <65 years and the males within this age group had an adjusted HR of 1.47 (95% CI 1.10 to 1.98) and an adjusted HR of 2.00 (95% CI 1.38 to 2.91) for AMI development, respectively. RVO was significantly associated with AMI development. Nature Publishing Group 2016-02-29 /pmc/articles/PMC4770309/ /pubmed/26924150 http://dx.doi.org/10.1038/srep22351 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Rim, Tyler Hyungtaek
Han, John Seungsoo
Oh, Jaewon
Kim, Dong Wook
Kang, Seok-Min
Chung, Eun Jee
Retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study
title Retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study
title_full Retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study
title_fullStr Retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study
title_full_unstemmed Retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study
title_short Retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study
title_sort retinal vein occlusion and the risk of acute myocardial infarction development: a 12-year nationwide cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770309/
https://www.ncbi.nlm.nih.gov/pubmed/26924150
http://dx.doi.org/10.1038/srep22351
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