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Effects of Active‐Site Modification and Quaternary Structure on the Regioselectivity of Catechol‐O‐Methyltransferase

Catechol‐O‐methyltransferase (COMT), an important therapeutic target in the treatment of Parkinson's disease, is also being developed for biocatalytic processes, including vanillin production, although lack of regioselectivity has precluded its more widespread application. By using structural a...

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Detalles Bibliográficos
Autores principales:	Law, Brian J. C., Bennett, Matthew R., Thompson, Mark L., Levy, Colin, Shepherd, Sarah A., Leys, David, Micklefield, Jason
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770447/ https://www.ncbi.nlm.nih.gov/pubmed/26797714 http://dx.doi.org/10.1002/anie.201508287

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